芪胶升白胶囊对预防鼻咽癌患者同步放化疗后骨髓抑制疗效观察  

Preventive effect of Qijiao Shengbai Capsule on myelosuppression in patients with nasopharyngeal cancer during concurrent chemoradiotherapy

作　　者：武新虎[1] 蒋璐[1] 邓芸[1] 朱锡旭[1] 姜万荣[1] 王振[1] 王义辉[1] 沈泽天[1] 

机构地区：[1]南京军区南京总医院放射治疗科,江苏南京210002

出　　处：《实用肿瘤杂志》2013年第2期203-206,共4页Journal of Practical Oncology

摘　　要：目的观察芪胶升白胶囊在鼻咽癌患者同步放化疗所致骨髓抑制中的治疗作用。方法 90例同步放化疗过程中出现骨髓抑制的局部晚期鼻咽癌患者随机分为3组,实验组:芪胶升白胶囊+重组人粒细胞集落刺激因子(recombinant human granulocyte colony-stimulating factor,G-CSF);对照1组:利血生+G-CSF;对照2组:单独使用G-CSF,治疗同步放化疗所致骨髓抑制,比较其疗效及不良反应。结果治疗结束时,实验组与对照1、2组在骨髓保护方面,差异有统计学意义(P<0.05);同步放化疗结束后,及结束后1、2周,实验组较对照1、2组骨髓抑制发生率明显降低,差异均有统计学意义(P<0.05),且无不良反应。结论芪胶升白胶囊对于同步放化疗所致的白细胞下降治疗作用显著,同时可以起到较好的骨髓保护作用,且无明显不良反应,价格低廉,可作为放化疗骨髓抑制时的常规口服用药。Objective To evaluate the preventive effect of Qijiao Shengbai Capsule on myolosuppression in patients with nasopharyngeal carcinoma （NPC） during concurrent chemoradiotherapy. Methods Ninety patients with local advanced NPC were randomly divided into three groups：the test group was treated with Qijiao Shengbai Capsule combined with G-CSF; the control group 1 ： leueogen tablets combined with recombinant human granulocyte colony-stimulating factor（G-CSF） ; the control group 2：G-CSF only. The white blood cell counts were measure before and 1 and 2 weeks after treatment. Results In the protection of myelosuppression,the test group was superior to the control group （ P 〈 O. 05 ）. Compared to the control group 1 and 2, the rate of bone marrow depression in test group was significantly lower in the end of concurrent chemoradiotherapy （ P 〈 0.05 ）. Conclusion Qijiao Shengbai Capsule is effective to prevent bone marrow depression and to raise WBC count in patients with local advanced nasopharyngeal carcinoma under concurrent chemoradiotherapy.

关 键 词：鼻咽肿瘤 放射疗法 鼻咽肿瘤 药物疗法 鼻咽肿瘤 预防和控制 综合疗法 随机对照试验 胶囊 骨髓 药物作用 

分 类 号：R739.63[医药卫生—肿瘤] R730.55[医药卫生—临床医学]