高渗盐水治疗家兔大脑中动脉栓塞的颅内高压的实验研究  

Hypertonic Saline in Treatment of Rabbits with Intracranial Hypertension Induced by Cerebral Medium Sized Artery Embolization

作　　者：李莉[1] 李国晖[2] 杨燕[2] 尧雪州[1] 

机构地区：[1]云南中医学院基础学院,云南昆明650500 [2]云南中医学院第一附属医院放射科,云南昆明650021

出　　处：《昆明医科大学学报》2013年第2期23-26,共4页Journal of Kunming Medical University

基　　金：云南省教育厅科学研究基金资助项目(2012Y065)

摘　　要：目的探讨高渗盐水治疗家兔大脑中动脉栓塞的颅内高压的效果.方法选用符合普通级的实验家兔30只,随机分成3组,每组10只,分别给以7.5%NaCL、23.4%NaCl和25%甘露醇,测定并比较不同处理组的颅内压及脑组织含水量情况.结果在造模前,3个处理组颅内压相同无统计学差异(P>0.05),3组的基础颅内压均在9 mmHg左右.3组分别给以不同液体30 min后,HS-1组颅内压稍有变化无统计学差异(P>0.05),另2组HS-2组和MNT组颅内压较造模前明显降低(P<0.05),另外,HS-2组和MNT组给药前后的颅内压差值无统计学差异(P>0.05),而两者给药前后的颅内压差值均高于HS-1组(P<0.05).HS-2组和MNT组脑组织含水量相同无统计学意义(P>0.05),2组脑组织含水量均高于HS-1组(P<0.05).结论 23.4%NaCl溶液能产生与20%甘露醇相似的降颅内高压效应,高渗盐水可以替代甘露醇用于降低颅内高压,但是在给药时,应当采用比甘露醇更高的渗透摩尔浓度和使用较高的剂量.Objective To explore the effect of hypertonic saline in treatment of rabbits with intracranial hy- pertension induced by cerebral medium sized artery embolization. Methods Thirty rabbits were randomly divided into three groups, each group of l0 rabbits. 7.5% NaCL, 23.4% NaC1 and 25% mannitol were given to rabbits in three groups, respectively, then the intracranial pressure and cerebral tissue water content of rabbits in three groups were determined and compared. Results There was no significant difference in the intracranial pressure among three groups before modeling （P〉0.05） , and the basic value of intracranial pressure in three groups was about 9 mmHg. 30min after giving different liquids, the intracranial pressure of rabbits in HS-1 group had slight change but had no significant difference （P〉0.05） ; the intracranial pressure of rabbits in other two groups （ HS-2 group and the MNT group） was significantly lower than before modeling （P 〈0.05） ; and the intracranial pressure value in HS-2 and MNT group had no significant difference between before and after treatment （P〉0.05） , while the in- tracranial pressure differential values between before and after treatment were higher than the HS-group 1 （P 〈 0.05） . The brain tissue water content had no statistically significant difference between HS-2 group and MNT group （P〉 0.05）, but was higher in HS-2 group and MNT group than HS-1 group （P 〈0.05）. Conclusion 23.4% NaC1 solution has similar effect to 20% mannitol in reducing intracranial hypertension, hypertonic saline can substi- tute mannitol to reduce intracranial hypertension, but the administration osmolality and doses should be higher than mannitol.

关 键 词：高渗盐水 大脑中动脉栓塞 动物实验 家兔 

分 类 号：R364.17[医药卫生—病理学]