青岛市区前列腺癌与家族史、婚育史关系的病例对照研究  

A case-control study on correlations of prostate cancer with sexual and marital factors and family history of cancers in the population of Qingdao City

作　　者：朱磊一[1] 翁博文[1] 贾勇[1] 高健刚[1] 孙小庆[1] 刘之俊[1] 祝海[1] 侯四川[1] 

机构地区：[1]青岛市市立医院东院泌尿外科,山东青岛266071

出　　处：《现代泌尿外科杂志》2013年第2期178-180,共3页Journal of Modern Urology

基　　金：青岛市科技计划基础研究项目(No.10-3-4-10-1-jch)

摘　　要：目的了解青岛市区前列腺癌发病与家族史及婚育史的关系,为前列腺癌的科学防治提供理论依据。方法在青岛市市立医院开展一项病例对照研究(1∶2配对),匹配条件为年龄组、性别、民族和居住地类型相同。调查以面谈为主,辅以调查病历记录,采用条件Logistic回归法分析数据。结果以其他疾病作为对照,家族中有恶性肿瘤患者前列腺癌的风险是无亲属患恶性肿瘤者的2.58倍;首次遗精年龄≤14岁者患前列腺癌的风险是≥18岁者的2.27倍;而首次性交年龄在25～30岁者是前列腺癌的保护因素,OR=0.76;35岁以前性生活频率≥4次/周与手淫≥3次/周者患前列腺癌风险明显增高,OR分别为2.57、2.30。结论肿瘤家族史、首次遗精年龄较早、35岁前性生活频繁、手淫频繁均为前列腺癌的危险因素。Objective To investigate the correlations of prostate cancer with sexual and marital factors and family history of cancers in the population of Qingdao City.Methods A hospital-based case-control study was conducted from 2008 to 2011 in Qingdao Municipal Hospital.The cases and controls were matched by age,gender,nation and place of residence.All the subjects were interviewed face to face in the hospital by experienced investigators.The data were analyzed with Conditional Logistic Regression Model.Results Compared with men without family history of cancers,men with family history of cancers had an increased risk of prostate cancer（OR=2.58）.Men who had the first spermatorrhea under 15 years old had higher risk of prostate cancer than those who had the first spermatorrhea over 18（OR=2.27）.A decreased risk of prostate cancer was found among those who had the first spermatorrhea between 25 to 30 years of age（OR=0.76）.Frequent sexual intercourse before 35 years old（OR=2.57）,and frequent masturbation（OR=2.30） increased the risk of prostate cancer.Conclusions Positive family history of cancers,the first spermatorrhea at an early age of,frequent sexual intercourse before 35 years old,and frequent masturbation are risk factors for prostate cancer.

关 键 词：前列腺癌 流行病学 危险因素 家族史 婚育史 病例对照研究 

分 类 号：R737.9[医药卫生—肿瘤]