非症状性癫痫患者血清胱抑素C的表达及意义  

Expression of serum cystatin C in patients with non-symptomatic epilepsy and its clinical significance

作　　者：刘凤英[1] 蔡学坤[1] 谭敏玲[1] 

机构地区：[1]广州医学院第三附属医院神经内科,510150

出　　处：《实用医学杂志》2013年第7期1078-1080,共3页The Journal of Practical Medicine

基　　金：广东省科技计划项目(编号:粤科规划字[2010]170号)

摘　　要：目的:探讨胱抑素C(cystatin C,Cys C)在非症状性癫痫发病机制中的作用。方法:采用胶乳增强免疫比浊法测定33例癫痫患者(实验组)和33例正常人(对照组)血清CysC的水平。结果:实验组CysC血清水平[(1.14±0.41)mg/L]明显高于对照组[(0.86±0.15)mg/L],差异具有统计学意义(P<0.01),各组CysC血清水平性别差异无统计学意义(P>0.05)。结论:高水平的血清CysC可能为癫痫的血生化标志之一,并可能对研究治疗癫痫的新药提供理论基础。Objective To explore the role of＂ cystatin C （Cys C） in the pathogenesis of non-symptomatic epilepsy. Methods Serum levels of Cys C were determined by latex-enhanced immunoturbidimetry assay in 33 epilepsy patients （study group） and 33 healthy people （control group）. Results Serum Cys C levels were significantly higher in the study group than in the control group [ （ 1.14 ± 0.41 ） mg/L vs （0.86 ±0.15 ） mg/L, P 〈 0.01 ] ; however, there was no significant difference in Cys C level between males and females in both groups （P 〉 0.05）. Conclusions Elevated level of Cys C may be one of the biochemical markers of epilepsy, which can provide theoretical support for producing new medications for epilepsy.

关 键 词：癫痫 胱抑素C 胶乳增强免疫比浊法 生化标志 

分 类 号：R742.1[医药卫生—神经病学与精神病学]