国内帕罗西汀与阿米替林治疗抑郁症疗效的Meta分析  

Meta-analysis of clinical efficacy of paroxetine vs amitriptyline in the treatment of depression

作　　者：姚俐[1] 梁一超[1] 陈伟军[1] 钟晓娟[1] 谢炜[2] 

机构地区：[1]南方医科大学中医药学院,广州市510515 [2]南方医科大学南方医院中医科,广州市510515

出　　处：《实用医学杂志》2013年第7期1168-1171,共4页The Journal of Practical Medicine

基　　金：广东省科技计划课题(编号:2008B080701028)

摘　　要：目的:评价国内帕罗西汀与阿米替林治疗抑郁症疗效的差异。方法:对15篇符合纳入标准的研究应用循证医学方法评价帕罗西汀与阿米替林治疗抑郁症的有效率、治愈率方面的差异。结果:帕罗西汀组在治愈率(215/421vs183/430,RR=1.19,95%CI:1.04～1.36,Z=2.51,P<0.05)方面明显优于阿米替林组,在有效率(342/421vs328/430,RR=1.05,95%CI:0.99～1.12,Z=1.65,P>0.05)方面无明显差异。结论:帕罗西汀与阿米替林两者在有效率方面无明显差异,但帕罗西汀治愈率明显优于阿米替林。Objective To evaluate the efficacy of paroxetine vs amitriptyline in the treatment of depression. Methods 15 studies meeting our criteria were analyzed with the use of evidence-based medicine method, with the curative efficacy such as the effective rate, curative rate and the change in symptoms of paroxetine vs amitriptyline evaluated comparatively. Results The paroxetine was significantly better than amitriptyline in curative rate （215/ 421 vs 183/430, RR=1.19, 95% CI 1.04 - 1.36,Z = 2.51 ,P 〈 0.05）, but there was no significant difference in effective rate （342/421 vs 328/430,RR = 1.05,95% CI 0.99 - 1.12,Z = 1.65,P 〉 0.05）and the symptom improvement in paroxetine was similar to amitriptyline. Coulusions There is no significant difference in effective rate and the symptom improvement, but the paroxetine has better curative rate than amitriptyline for depression.

关 键 词：帕罗西汀 阿米替林 抑郁症 META分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学]