阿托伐他汀对急性脑梗死患者血清抵抗素和脂联素的作用  

Effect of atorvastatin on serum levels of resistin and adiponectin in patients with acute cerebral infarction

作　　者：麦晖[1] 周海虹[1] 赵斌[1] 

机构地区：[1]广东医学院附属医院神经内科,湛江524001

出　　处：《中国实用神经疾病杂志》2013年第6期19-21,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨急性脑梗死(ACI)患者应用阿托伐他汀治疗后血清抵抗素和脂联素水平的变化。方法选择我院2010-07—2012-06收治的ACI患者76例随机分为对照组(n=38)和观察组(n=38),对照组给予常规治疗,观察组在常规治疗基础上加用阿托伐他汀治疗,均治疗2周,观察比较2组治疗前后的血脂、高敏C反应蛋白(hs-CRP)、血清抵抗素、脂联素水平变化及不良反应发生情况。结果 2组治疗后TC、TG、LDL-C、hs-CRP水平均较治疗前明显下降,差异有统计学意义(P<0.05);治疗后观察组较对照组下降更显著,差异有统计学意义(P<0.05);2组治疗后HDL-C水平比较,差异无统计学意义(P>0.05)。2组治疗后血清抵抗素明显下降,脂联素水平明显升高,2组治疗前后比较,差异有统计学意义(P<0.05);观察组治疗后比对照组改善明显,2组治疗后比较差异有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿托伐他汀可有效降低ACI患者的血脂及hs-CRP,明显改善血清抵抗素和脂联素水平,防止形成动脉粥样硬化性脑梗死。Objective To investigate the effect of atorvastatin on the serum levels of resistin and adiponectin in patients with acute cerebral infarction. Methods Seventy-six patients with acute cerebral infarction admitted to our hospitat from July 2010 to June 2012 were randomly divided into control group （n=38） and observation group （n=38）. The control group was given conventional treatment and the observation group was treated with atorvastatin on the basis of conventional therapy. After two weeks treatment, the levels of blood lipids, high sensitivity C-reactive protein （hs-CRP）, resistin and adiponectin as well as adverse reactions were observed and compared between the two groups. Results After treatment, the levels of TC, TG, LDL-C, and hs-CRP were significantly lower than those before treatment in two group（P〈0.05） ; the levels of above pa- rameters of the observation group were significantly lower than those of control group（P〈0.05）. There was no significant difference of the level of HDL-C between the two groups after treatment（P〉0.05）. After treatment, the serum levels of resistin and adiponectin were significantly improved of the observation group than those of control group（P〈0.05）. There was no significant difference of adverse reactions between the two groups（P〉0.05）. Conclusion Atorvastatin can effectively reduce the levels of blood lipid and hs-CRP and significantly improve serum levels of resistin and adiponeetin in treating acute cerebral infarction, so as to prevent the formation of atherosclerotic cerebral infarction.

关 键 词：阿托伐他汀 急性脑梗死 抵抗素 脂联素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]