颈内动脉狭窄患者脑血管储备能力的研究  

Cerebrovascular reserve in patients with internal carotid artery stenosis

作　　者：林颖[1] 孔丽[1] 戴加飞[1] 刘海波 李敏[1] 郭芮兵[1] 陈光辉[1] 刘玲[1] 杨昉[1] 

机构地区：[1]南京军区南京总医院神经内科,210002 [2]南京军区空军司令部门诊部内科

出　　处：《中华老年心脑血管病杂志》2013年第4期379-381,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(81070923;81100870);南京军区南京总医院院管课题资助项目(2011045)

摘　　要：目的探讨脑血管储备能力(cerebrovascular reserve,CVR)与一侧颈内动脉狭窄程度的关系。方法选择脑梗死患者85例,其中颈内动脉狭窄组59例,对照组26例。分别通过吸入5%CO2和95%O2混合气体诱发高碳酸血症,计算大脑中动脉血流速度变化。结果颈内动脉狭窄组患者CVR较对照组明显降低[(22.47±12.45)%vs(37.25±11.77)%,P<0.01]。CVR与颈内动脉狭窄程度呈负相关(CI=-0.6587,P<0.01)。颈内动脉狭窄是CVR下降的独立危险因素(OR=5.149,95%CI:2.682～9.858,P<0.01)。结论颈内动脉狭窄是影响CVR的独立危险因素,检测CVR可能预测颈内动脉狭窄程度。Objective To study the relation between cerebrovascular reserve（CVR） and unilateral internal carotid artery（ICA） stenosis. Methods Eighty-five patients with cerebral infarction（ineluding 59 patients with ICA stenosis） served as an ICA stenosis group and 26 patients without ICA stenosis served as a control group in this study. Hypercapnia was induced by inhaling 5% CO2 and 95%O2 mixed gas. The blood flow rate in middle cerebral artery was measured. Results The CVR was significantly lower in ICA stenosis group than in control group （22.47%± 12.45% vs 37.25%±11.77% ,P〈0. 01）. The CVR was positively correlated with the severity of ICA stenosis（CI=-0. 6587, P〈0.01）, indicating that ICA stenosis is an independent factor for the reduced CVR（OR=5.149,95%CI：2. 682--9. 858,P〈0. 01）. Conclusion ICA stenosis is an independent factor for CVR and detection of CVR can predict the severity of ICA stenosis.

关 键 词：颈动脉狭窄 脑梗死 血流速度 高碳酸血 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]