三氟甲磺酸钐催化合成芳酰腈类化合物  

the Synthesis of Aromatic Acyl Cyanides Catalyzed by Sm(OTf)3

作　　者：吴敖荣[1] 毛达杰[1] 刘建华[1] 杜晓华[1] 

机构地区：[1]浙江工业大学催化加氢研究中心,杭州310014

出　　处：《农药》2013年第4期241-243,246,共4页Agrochemicals

摘　　要：[目的]研究芳酰腈化合物的合成新方法。[方法]在三氟甲磺酸钐的催化下,芳酰氯与氰化钠反应得到相应的芳酰腈类化合物。[结果]最佳条件下,芳酰腈类化合物的收率达90%左右,纯度98%以上。[结论]该路线反应条件温和,选择性高,无需使用相转移催化剂,为芳酰腈类化合物提供了一种实用的新合成方法。[Aims] The paper aims to study a new synthetic method of aromatic acyl cyanides. [Methods] Catalyzed by Sm（OTf）3, aromatic acyl chlorides was reacted with sodium cyanide to give aromatic acyl cyanides. [Results] Under the optimal reaction conditions, the yields and purities of aromatic acyl products reached about 90% and above 98% respectively. [Conclusions] It is a novel practical method to prepare aromatic acyl cyanides, with mild reaction conditions and high selectivity, and without the use of phase transfer catalyst.

关 键 词：三氟甲磺酸盐 LEWIS酸 氰化钠 酰腈化合物 

分 类 号：TQ450.1[化学工程—农药化工]