叔丁基羟基茴香醚对小鼠醋氨酚中毒性肝损伤的保护作用  

Protective Effects of 2(3)-tert-butyl-4-hydroxyanisole against Hepatotoxicity Induced by Acetaminophen in Mice

作　　者：程燕 王立新[1] 林三仁[1] 

机构地区：[1]北京医科大学附属第三医院消化疾病研究中心,新加坡大学100083

出　　处：《胃肠病学》2000年第2期109-111,共3页Chinese Journal of Gastroenterology

摘　　要：目的：采用小鼠醋氨酚中毒性肝损伤模型探讨2（3）-叔丁基小羟基茴香醚（BHA）对肝脏的保护作用。方法：通过腹腔注射醋氨酚制备小鼠肝损伤模型，测定小鼠血清丙氨酸转氨酶（ALT）活性和肝匀浆液中的丙二醛（MDA）含量、超氧化物歧化酶（SOD）活性及谷胱甘肽（GSH）含量。结果：0．2％及0．5％的BHA都能显著对抗醋氨酚所致小鼠肝损伤的血清ALT活性升高，肝组织MDA含量升高、SOD活性降低及还原型GSH耗竭。结论：BHA对醋氨酚所致肝损伤具有保护作用，其作用机制可能与加强自由基的清除和抗脂质过氧化有关。Background/Aims: To investigate the protective effects of 2(3)-tert-butyl-4-hydroxyanisole(BHA) on liver injury induced by acetaminophen in mice. Methods: Liver injuries were induced by acetaminophen injected intraperitoneally, serum ALT, and MDA, SOD, GSH in the liver were determined.Results: Both 0.2% and 0.5% of BHA markedly suppressed the elevation of serum ALT and liver MDA induced by acetaminophen, they also inhibited the decrease of liver SOD and GSH contents in acetaminophen treated mice. Conclusions: BHA could significantly prevent the liver injury caused by acetaminophen. The protective mechanism of BHA might include the increase in scavenging of free radicals and inhibition of lipid peroxidation.

关 键 词：丁羟茴香醚 醋氨酚 肝疾病 细胞保护 

分 类 号：R575[医药卫生—消化系统]