麻黄素滴鼻治疗偏头痛的研究  

THERAPEUTIC EFFECTS OF INTRANASAL MEDICATION WITH EPHERINE ON MIGRAINE

作　　者：张微微[1] 郝小淑[1] 杨建新[1] 黄勇华[1] 

机构地区：[1]北京军区总医院神经内科,北京100700

出　　处：《中国疼痛医学杂志》2000年第3期136-139,共4页Chinese Journal of Pain Medicine

摘　　要：目的 :本文采用 1 %麻黄素滴鼻方法治疗偏头痛患者 48例。方法 :通过脑阻抗血流图 (Reoencephalogram ,REG)进行了治疗前后的观察对比研究。结果 :发现麻黄素滴鼻对无先兆型和有先兆型偏头痛均有效。总有效率分别为 96 .8%和 82 .4% ,REG的流入时间、波幅、转折高比值、重搏波、波形及波幅差均见明显的变化。提示麻黄素自鼻粘膜吸收后 ,迅速作用于过度扩张的颅外血管 ,通过颅外和颅内血管间的交通 ,对颅内血管也具有一定的收缩作用。结论Objective: To investigate the effects of intranasal medication with epherine on Migraine. Methods: Thirty one migraineurs without aura and seventeen cases with aura were treated with 1% epherine and the reoencephalograms were observed. Results: The total improvement rate of Migraine without aura and with aura were 96.8% and 82.4% respectively. There were significant changes on reoencephalogram between pretreatment and post treatment in the patients with Migraine. Conclusion: The intranasal route of drug administration (eg. Epherine) is feasible and promising for the treatment of patients with migraine.

关 键 词：偏头痛 麻黄素 脑阻抗血流图 滴鼻法 

分 类 号：R747.2[医药卫生—神经病学与精神病学]