抗精神病药物对稳定期慢性精神分裂症患者P50的影响  

Effects of Antipsychotics on P50 of Chronic Schizophrenic Inpatients in Stable Stage

作　　者：朱孔美[1,2] 王东[1,2] 谭淑平[2] 邹义壮[2] 杨甫德[2] 周东丰[3] 

机构地区：[1]威海市精神卫生中心,山东威海264205 [2]北京回龙观医院 [3]北京大学精神卫生研究所

出　　处：《中国民康医学》2013年第5期11-14,共4页Medical Journal of Chinese People’s Health

基　　金：北京市科委重大项目资助专项(D0906001000091);北京市优秀人才基金(2007id0301400101)

摘　　要：目的:探讨抗精神病药物对稳定期慢性精神分裂症患者感觉门控指标-P50的影响。方法:选取137例稳定期慢性精神分裂症患者,采用条件-测试刺激模式记录脑电信号并进行离线分析,测量P50的波幅和潜伏期进行统计比较。结果:典型组与非典型组P50指标没有差异(P>0.05)。氯氮平组与利培酮组比较,S2波幅、S2潜伏期、S2/S1、1-S2/S1差异均有显著性(P<0.05)。药物剂量与P50各指标没有相关性。结论:抗精神病药能改善精神分裂症患者的P50功能,不同的药物对其影响不同。Objective：To explore the effects of antipsychotics on PS0 of chronic schizophrenic inpatients in stable stage. Methods ：The study involved 137 chronic schizophrenics. PS0 was measured by using the conditioning/testing paradigm presented with auditory double clicks stimuli. Results： There were no significant difference between typical group and atypical group （ P 〉 0.05 ）. There were significantly different of S2V, S2L, s2/S1 and 1 - s2/S1 between Clozapine group and Risperidone group （ P 〈 0.05 ）. There was no correlation between drugs doses and PS0. Conclusions ： Antipsychotics could improve the PS0 of chronic schizophrenics, and there were significant different effects among the drugs.

关 键 词：精神分裂症 感觉门控 事件相关电位 P50 抗精神病药 

分 类 号：R749.3[医药卫生—神经病学与精神病学]