浦东新区门诊精神分裂症患者服药依从性对其预后的影响(2年随访)  

The impact of different compliance of outpatient schizophrenics on the prognosis(2-year follow-up)

作　　者：秦虹云[1] 张洁[1] 王振萍[1] 闵海瑛[1] 严彩英[1] 陈福珍[1] 傅伟忠[1] 张明[1] 

机构地区：[1]浦东新区精神卫生中心,上海200124

出　　处：《中国民康医学》2013年第5期15-17,共3页Medical Journal of Chinese People’s Health

基　　金：上海浦东新区卫生局科委资助(项目编号:PW2008A-19)

摘　　要：目的:将2007年1月1日至2008年12月31日浦东新区精神卫生中心门诊首次就诊的89例精神分裂症患者一年治疗的服药依从性分为依从性好组及依从性不良组,且进行2年随访,研究依从性对患者预后的影响。方法:采用自编、简明精神症状量表(BPRS),SIMH治疗副反应量表(TESS),MorningSide康复状态量表(MRSS),社会功能缺陷筛查量表(SDSS)等调查量表,将数据输入SPSS11.5,采用参数及非参数统计方法进行分析。结果:依从性不良组(n=37)的复发人数和平均复发次数明显多于依从性好组(n=52),差异有显著的统计学意义(P<0.01)。随访末期,两组的MorningSide康复状态量表(MRSS)和社会功能缺陷筛查量表(SDSS)评分均得到进一步的改善,差异有显著的统计学意义(P<0.01)。排除性别、年龄、精神疾病病程、心理干预及是否首发等因素后,复发次数与依从性的偏相关分析显示呈负相关(r=-0.2705,P=0.023)。结论:维持剂量越接近治疗剂量,复发的可能性越小。Objective ：To study the impact of different compliance of outpatient schizophrenics on the prognosis, who accepted their routine treatment in the clinics of Pudong Mental Health Centre from January 1 st 2007 to December 31 st 2008. Methods：All the patients were surveyed by the Self- edited Questionnaire which included the general health state, diagnoses, career, family care, education, etc, and the Brief Psychiatric Rating Scale（ BPRS）, SIMH Treatment Emergent Symptom Scale （TESS）, Morning Side Reha- bilitation Status Scale （ MRSS）, the Social Disability Screening Schedule （SDSS）. All the data were put in and analyzed with the soft- ware SPSS11.5. Results： Altogether, 89 schizophrenics were agreed to take part in the program and grouped into good compliance （n = 52） and poor compliance （ n = 37 ） according to their monthly prescribed records in the past whole year. There was significant differ- ences of the relapsed patients and episodes between the two compliance group（ P 〈 0.01 ）. And there were significant differences of the scales of MRSS and SDSS between the admission and the follow- up（ P 〈 0.01 ）. The partial correlation analysis revealed that relapse frequency and adherence had a negative correlation, after excluded of gender, age, the course of mental illness, psychological intervention and whether the first episode or not （r = -0.2705, P = 0.023 ）. Conclusions： The compliance of the first episode schizophren- ics need to be improved.

关 键 词：精神分裂症 服药依从性 随访 复发 

分 类 号：R749.3[医药卫生—神经病学与精神病学]