奥沙利铂联合5-氟尿嘧啶及亚叶酸钙治疗晚期胃癌的疗效研究  

Study on effect of Oxaliplatin combined with 5-Fluorouracil and Leucovorin Calcium in the treatment of advanced gastric cancer

作　　者：温爱萍[1] 

机构地区：[1]河北省唐山市乐亭县医院内4科,河北乐亭063600

出　　处：《中国医药导报》2013年第10期87-89,共3页China Medical Herald

摘　　要：目的观察奥沙利铂联合5-氟尿嘧啶(5-FU)及亚叶酸钙治疗晚期胃癌的疗效,并与ELF方案进行对比分析。方法入选的56例晚期胃癌患者中,接受奥沙利铂联合5-FU及亚叶酸钙化疗方案治疗的28例患者,设为A组,接受ELF方案化疗方案的28例患者,设为B组,比较两组的疗效、生活质量改善情况及不良反应情况。结果两组患者总有效率分别为53.6%、50.0%,差异无统计学意义(P>0.05)。两组患者术后生活质量的改善率分别为85.7%、57.1%,差异有统计学意义(P<0.05)。两组在中性粒细胞减少、恶心、呕吐、脱发、口腔黏膜炎、手足综合征方面的发生率比较,差异有统计学意义(P<0.05或P<0.01)。两组肝功能检查中胆红素及丙氨酸氨基转移酶升高不明显,差异无统计学意义(P>0.05)。结论奥沙利铂联合5-FU及亚叶酸钙治疗晚期胃癌能明显提高疗效,改善患者的生活质量,且不良反应少,值得广泛推广和应用。Objective To explore the efficacy of Oxaliplatin combined with 5-Fluorouracil （5-FU） and Leucovorin Calcium in the treatment of advanced gastric cancer, and to compare and analyze the effect with the ELF program. Methods 56 patients with advanced gastric cancer patients were selected as the study objects, and 28 patients who received Oxaliplatin combined with 5-FU and Leucovorin Calcium chemotherapy were selected as the group A, the other 28 patients who accepted ELF chemotherapy program were established as group B, the efficacy and improved rate of quality of life and adverse reactions were compared between two groups. Results The total efficiency rate of group A and group B was 53.6%, 50.0% respectively, the difference was not significant between two groups （P 〉 0.05）. Postoperative quality of life improvement rates of group A and group B was 85.7%, 57.1% respectively, the difference was significant between the two groups （P 〈 0.05）. The incidence of neutropenia, nausea, vomiting, alopecia, mucositis, and hand-foot syndrome had significant differences between two groups （P 〈 0.05 or P 〈 O.O1）. The liver function tests, bilirubin and alanine transaminase elevation was not obvious between two groups, the difference was not statistically significant different （P 〉 0.05）. Conclusion Oxaliplatin combined with 5-Fluorouracil and Leucovorin Calcium in the treatment of advanced gastric cancer can significantly improve the efficacy, improve the patient＇s quality of life, and has fewer adverse reactions, so it should be popularized and applied.

关 键 词：晚期胃癌 奥沙利铂 5-氟尿嘧啶 亚叶酸钙 

分 类 号：R735.7[医药卫生—肿瘤]