三维适形放射治疗同步奥利沙铂化疗治疗晚期局限性非小细胞肺癌的临床疗效  

Research on three dimensional conformal radiotherapy combined with concurrent Oxaliplatin in treatment of patients with limited advanced non-small cell lung cancer

作　　者：段宏燕[1] 

机构地区：[1]辽宁省肿瘤医院放疗科,沈阳110042

出　　处：《中国肿瘤临床与康复》2013年第3期232-234,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨三维适形放射治疗(3DCRT)同步奥利沙铂(L-OHP)化疗治疗晚期局限性非小细胞肺癌(NSCLC)的临床疗效。方法将入选的90例局限性NSCLC患者随机单盲分为A组(47例)和B组(43例),B组患者给予3DCRT放射治疗方案,A组患者在此基础上同步给予L-OHP化疗,对比两组患者治疗后临床疗效和不良反应。结果 (1)A组患者完全缓解率(10.6%)和总有效率(78.7%)均高于B组患者(7.0%和55.8%,P<0.05);(2)A组患者治疗后生活质量改善情况优于B组患者(Z=-2.155,P=0.031);(3)A组患者骨髓抑制、胃肠道反应、末梢神经损害和放射性肺损伤发生率高于B组患者(P<0.05)。结论 3DCRT放射治疗同步L-OHP化疗能提高NSCLC患者病灶的近期控制率,但应做好对联合放化疗期间出现不良反应的对症处置。Objective To explore the clinical effect of dimensional conformal radiotherapy（3DCRT） combined with concurrent Oxaliplatin（L-OHP） in treatment of patients with limited advanced non-small cell lung cancer（NSCLC）.Methods 90 admitted patients were randomly divided into A group（47 cases）and B group（43 cases）,B group was treated with 3DCRT regime,based on which A group was applied L-OHP therapy,and clinical efficacy,toxic side reactions were compared between two groups.Results（1）Complete remission rate total efficiency rate of A group were higher than those of B group（P0.05）;（2）Obvious improvement of quality of life of A group was superior to B group（Z=-2.155P=0.031）;（3）During treatment,incidence rate of myelosuppression,gastrointestinal tract reaction,peripheral nerve damage,radiation induced lung injury in Agroup was higher than that of B group（P0.05）.Conclusions 3DCRT radiotherapy combined with concurrent L-OHP chemotherapy in treatment of limited advanced NSCLC can improve control rate of primary lesion,but attention also should be paid to symptomatic disposal for toxicity reactions.

关 键 词：三维适形放疗 奥利沙铂 疗效 不良反应 

分 类 号：R734.2[医药卫生—肿瘤]