乳腺癌与甲状腺疾病相关性的临床研究  

Clinical research on the relationship between breast cancer and thyroid disorder

作　　者：赵艳杰[1] 王睿斌[2] 宋雨光[1] 任军[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院肿瘤内科,100038 [2]首都医科大学大兴医院肛肠科

出　　处：《肿瘤研究与临床》2013年第3期178-180,共3页Cancer Research and Clinic

摘　　要：目的探讨乳腺癌患者自身免疫与非自身免疫甲状腺疾病的发病情况。方法选择100例乳腺癌手术患者，以同期相对应年龄无乳腺疾病及甲状腺疾病病史女性100名为对照组，通过临床检查、B型超声、甲状腺素及抗体水平检查、细针穿刺活组织检查等对比甲状腺疾病的发病情况。结果乳腺癌患者抗甲状腺过氧化物酶抗体明显高于对照组[（104．56±21．54）U／ml比（22．16±4．65）u／ml，P=0．030]。乳腺癌组自身免疫与非自身免疫甲状腺疾病的发病率高于对照组[38％（38／100）比17％（17／100），P=0．0009；26％（26／100）与9％（9／100），P=0．0016]。结论乳腺癌患者的自身免疫与非自身免疫甲状腺疾病的发病率高于非乳腺癌者。Objective To investigate the incidence of autoimmune and nonautoimmune thyroid diseases in patients with breast cancer. Methods Clinical and ultrasound evaluation of thyroid gland, detection of serum thyroid hormone and related antibodies, and fine-needle aspiration of thyroid gland were performed in 100 breast cancer patients and 100 control individuals during the period from 2004 to 2008. Results The mean values of anti-thyroid peroxidase antibodies were significantly higher in breast cancer patients than that in control individuals [（104.56±21.54） U/ml vs （22.16±4.65） U/ml, （P= 0.030）]. The incidence rates of autoimmune and nonautoimmune thyroid diseases were higher in breast cancer patients than that in control individuals [38 % （38/100） vs 17 % （17/100）, P = 0.0009, 26 % （26/100） vs 9 % （9/100）, P = 0.0016, respectively]. Conclusion The results indicate an increased incidence of autoimmnne and nonautoimmune thyroid diseases in breast cancer patients.

关 键 词：乳腺肿瘤 甲状腺疾病 

分 类 号：R737.9[医药卫生—肿瘤]