结直肠癌术后腹腔引流液CEA、CA125、CA19-9的检测与肿瘤淋巴转移的相关性分析  

Levels of CEA, CA125, CA19-9 in intraperitoneal drainage after resection of colorectal cancer and their relationship with lymph node metastasis

作　　者：王碧玉 庄晓泉 黄芳 赵勇 向俾庭 

机构地区：[1]桂林市人民医院检验科,广西桂林541002 [2]桂林市人民医院普通外科,广西桂林541002

出　　处：《海南医学》2013年第8期1154-1156,共3页Hainan Medical Journal

基　　金：桂林市科技局科研基金项目(编号:20120121-5-2)

摘　　要：目的探讨结直肠癌术后腹腔引流液中肿瘤标志物CEA、CA125、CA19-9浓度与肿瘤淋巴结转移的相关性。方法检测55例结直肠癌患者术后第1、2天腹腔引流液中肿瘤标志物CEA、CA125、CA19-9的浓度,并按照有无淋巴结转移进行分组。结果术后第1、2天无淋巴结转移组与有淋巴结转移组腹腔引流液中CEA浓度比较差异有统计学意义,无淋巴结转移组CEA浓度低于有淋巴结转移组,CA19-9、CA125浓度比较差异无统计学意义;无淋巴结转移组第1、2天腹腔引流液CEA、CA125浓度比较差异有统计学意义,第2天CEA浓度低于第1天,CA125浓度高于第1天,CA19-9比较差异无统计学意义;有淋巴结转移组术后第1、2天腹腔引流液中CEA、CA19-9、CA125浓度比较差异无统计学意义。结论结直肠癌患者术后早期腹腔引流液中CEA浓度的表达与肿瘤的淋巴结转移具有正相关性,而CA19-9和CA125临床价值不大。Objective To investigate the levels of tumor markers （CEA, CA125, CA19-9） in intraperitoneal drainage after resection of colorectal cancer, and their relationship with lymph node metastasis. Methods Fifty patients with colorectal cancer were enrolled in this study. The levels of tumor markers （CEA, CA125, CA19-9） were detected on the first, second day after resection. The patients were divided into two groups： group A （with lymph node metastasis） and group B （without lymph node metastasis）. Results After resection, the levels of CEA was significantly higher in group A than group B, and the levels of CA19-9 and CA125 showed no statistically significant difference between the two groups. In group B, the levels of CEA was significantly higher on the first day than the second day after resection, and the levels of CA125 was significantly lower on the first day, with no statistically significant difference in the levels of CA 19-9. In group A, the levels of CEA, CA 19-9, CA125 showed no statistically significant difference between the first day and the second day. Conclusion The levels of CEA in intraperitoneal drainage after resection in patients with colorectal cancer is positively correlated with lymph node metastasis, while CA19-9 and CA 125 have little clinical value.

关 键 词：结直肠癌 癌胚抗原 糖类抗原CA19—9 糖类抗原CA125 淋巴结转移 

分 类 号：R735[医药卫生—肿瘤]