乳腺癌^99mTc-MIBI显像与P-gp、Survivin表达的相关性研究  

Study on the Relationship of 99mTc-MIBI Scinigraphy with the Expression of P-gp and Survivin in Breast Cancer

作　　者：朱娴[1] 林小红[1] 

机构地区：[1]株洲市一医院,湖南株洲412000

出　　处：《医学临床研究》2013年第3期535-537,共3页Journal of Clinical Research

摘　　要：【目的】探讨乳腺癌中^99m鲟-甲氧基异丁基异腈（^99m—MIBI）的摄取、滞留与多药耐药相关蛋白P—gP、survivin表达的相关性。【方法】对52例乳腺癌患者进行”“Tc—MIBI乳腺显像：静脉注射显像剂”“Tc—MI—B11110Mbq（30mci），30min、120min后分别行^99m—MIBI乳腺显像，采用感性趣区（ROI）技术计算早期摄取比（Earlyuptakeratio，EUR）和延迟摄取比（Delayuptakeratio，DUR），计算肿瘤滞留指数（RetensionindexRI）、洗脱率（washoutratio，WOR），采用免疫组化法检测乳腺癌组织P—gP、survivin表达水平，并与TuR、RI、WOR进行相关性分析。【结果】P—gP表达阳性率57．7％（30／52）与survivin51．9％（27／52）比较差异无显著性（0—0．50，P〉0．05）；P—gP的表达与wOR成正相关，与DUR、RI成负相关，而与EUR无相关性；survivin的表达与^99mc—MIBI肿瘤显像无相关性。【结论】^99m—MIBI双时相显像（30min和120min）能较准确地预测乳腺癌多药耐药蛋白P—gP的功能状态，清除指数与P—gP表达呈正相关，^99m—MIBI显像具有检测乳腺癌患者肿瘤组织内P—gP表达的价值。[Objective]To explore the correlation of the absorption and retention of ^99m Tc-MIBI with the expression of multidrug resistance proteins P-glycoprotein（P pg） and survivin in breast cancer. [Methods]^99mTc-MIBI scintigraphy was performed for 52 patients with breast cancer. After intravenous injection with 99mTc-MIBIl110Mbq（30mci） for 30min and 120min respectively, ^99m Tc MIBI scintigraphy was performed. Region of interest（ROD technique was used to calculate the early uptake ratio（EUR） and delay uptake ratio（DUR）. Tumor retention index（RI） and washout ratio（WOR） were calculated. Immunohistochemistry method was used to detect the expression of P-gp and survivin. The correlation of the expression of P-gp and survivin with TUR, RI and WOR was analyzed. [Results]The positive ratio of P-gp expression was 57.7%（30/52）, but there was no significant difference between P-gp and survivin（51.9% 27/52）（X^2=0. 50, P 0.05）. The expression of P-gp was positively correlated with WOR, but negatively correlated with DUR and RI, and had no associated with EUR. There was no correlation between the expression of survivin and 99m Tc-MIBI scintigraphy. [Con- clusion] 99m Tc-MIBI hi-phase scintigraphy（30min and 120min） can accurately predict the state of multidrug resistance protein P-gp of breast cancer. Clear index is positively related with the expression of P-gp. ^99mTc-MIBI scintigraphy is valuable for detecting the expression of P-gp in tumor tissues of patients with breast cancer.

关 键 词：乳腺肿瘤 ^99m锝甲氧基异丁基异腈 

分 类 号：R737.9[医药卫生—肿瘤]