牙源性角化囊性瘤开窗减压术后组织形态学改变  

The postoperative histomorphological changes of keratocystic odontogenic tumor after decompression

作　　者：王婧[1] 武和明[1] 王丽珍 张玮[3] 丁旭[1] 邢树忠[1] 

机构地区：[1]南京医科大学口腔医学研究所.附属口腔医院颌面外科,江苏南京210029 [2]上海第九人民医院口腔病理科,上海200011 [3]南京医科大学附属口腔医院病理科

出　　处：《口腔生物医学》2013年第1期40-43,共4页Oral Biomedicine

基　　金：江苏高校优势学科建设工程资助项目

摘　　要：目的:探讨牙源性角化囊性瘤(keratocysitic odontogenic tumor,KCOT)开窗减压术后组织形态学的改变。方法:对比观察22例牙源性角化囊性瘤开窗减压术前及二期刮治术后组织学的改变,内容包括上皮形态、上皮及纤维层厚度、纤维层炎症浸润程度,并行统计学分析。结果:54.5%的病例开窗后上皮层不全角化消失同时出现钉突状增生;开窗后衬里上皮及纤维囊壁层明显增厚(P<0.05);纤维层内炎症浸润程度显著加重(P<0.05)。结论:牙源性角化囊性瘤在开窗减压术后表现出衬里上皮及纤维囊壁显著增厚和纤维层内炎症细胞浸润加重的组织形态学特征,其具体机制及意义还需进一步研究。Objective ： To investigate the histomorphological changes of the keratocystic odotogenic tumor after decompression. Methods ： The histomorphological changes of 22 KCOT tissue slices stained with hematoxylin and eosin before decompression and after curettage were observed, including the epithelial modality, the depth of the epithelium and connective tissue, the degree of inflammation infiltration in the layer of connective tissue, and then statistic analysis were made. Results：54.5 percent of the cases were found the appearance of localized hyperplasia with rete pegs. The thickness of both epithelium and connective tissue layer increased statistically after decompression （ P 〈 0.05 ） and the degree of inflammation infiltration also intensified dramatically （ P 〈 0.05 ）. Conclusions ： The histomorphological features of KCOT have changed remarkably after decompression, appearing as the thickened linings and intensified inflammation infiltration,further research is needed to explain the mechanism of the above-mentioned changes.

关 键 词：牙源性角化囊性瘤 开窗减压术 组织形态学 

分 类 号：R739.82[医药卫生—肿瘤]