Bcl-2在胃癌中的表达及其临床意义  

Expression and clinical significance of Bcl-2 in gastric carcinoma

作　　者：任磊[1] 周业江[1] 刘春凤[2] 

机构地区：[1]泸州医学院附属医院胃肠外科,泸州646000 [2]泸州医学院附属医院呼吸内科

出　　处：《国际外科学杂志》2013年第3期164-166,F0003,共4页International Journal of Surgery

摘　　要：目的研究B细胞淋巴瘤／白血病-2基因（Bcl-2）在胃癌中的表达，以探讨其与胃癌临床生物学行为和预后的关系。方法应用免疫组织化学SP法分别检测Bcl-2在42例胃癌患者的胃癌及切缘上皮组织中的表达。结果Bcl-2在胃癌和胃切缘上皮组织中的阳性表达率分别为69．05％和21．43％，两者差异有统计学意义（P〈0．05）；Bcl-2表达水平与胃癌患者的年龄、性别和浸润深度无关（P〉0．05），而与肿瘤分化程度、TNM分期、淋巴结转移有关（P〈0．05）。结论胃癌中Bcl-2表达可能是胃癌侵袭、转移、演进和预后的生物学标志之一。Objective To investigate the expression of B-cell lymphoma/leukemia-2 gene（Bcl-2） in the gastric carcinoma, and the relationship between Bcl-2 and clinical biological behaviour and prognosis. Methods To use SP immunohistochemistry to detect respectively the expression level of Bcl-2 in the gastric carcinoma and incisal margin epithelial tissue of 42 gastric carcinoma patients. Results The positive expression rates of Bcl-2 in the gastric carcinoma and incisal margin epithelial tissue were 69.05% and 21.43%. It had statistical significance （ P 〈 0.05 ） ; the expression of Bcl-2 in gastric carcinoma had not significantly correlation repectively with patient＇ s age, gender and invasive depth （ P 〉 0.05） , but had significantly correlation with differentiation, TNM stage and lymph node metastasis of the tumor （ P 〈 0.05）. Conclusion The expression level of Bcl- 2 in gastric carcinoma may be one of biology indexes of the invasion, migration, advancement and prognosis of the gastric carcinoma.

关 键 词：淋巴瘤 B细胞 胃肿瘤 癌 细胞凋亡 

分 类 号：R735.2[医药卫生—肿瘤]