胶质瘤中过氧化物酶体增殖物激活受体γ表达与预后的关系  

Relationship between Expression of Peroxisome Proliferators-activated Receptors γ in Gliomas and Outcome of Patients

作　　者：周长胜[1] 王进昆[1] 王伟民[1] 王崇谦[1] 尚亚军[1] 王波[1] 牟临杰[1] 张浩[1] 苏稳 丁鹏[1] 

机构地区：[1]昆明医科大学附属第一医院神经外科,云南昆明市650032

出　　处：《中国康复理论与实践》2013年第3期235-238,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：云南省科技厅-昆明医科大学联合专项基金(No.2010CD157)

摘　　要：目的探讨人脑胶质瘤组织中过氧化物酶体增殖物激活受体（PPAR）？表达水平与患者临床病理特征及预后的关系。方法采用免疫组织化学法检测48例人脑胶质瘤组织PPARyγ表达水平，Kaplan—Meier生存曲线比较PPARγ高表达组与低表达组患者的无进展生存期及总生存期。结果PPARy表达在I～IVN胶质瘤组织中随肿瘤恶性程度增加而降低（P〈0．01），表达水平与病理级别呈负相关（F=0．770，P〈0．01）。高表达组和低表达组无进展生存期和总生存期均有非常显著性差异（P〈0．01）。结论PPA聊表达与胶质瘤的恶性程度相关，可以为临床判断脑胶质瘤患者预后提供依据。Objective To explore the relationship among expression ofperoxisome proliferators-activated receptors γ （PPARγ） in human glioma, malignancy and outcome. Methods The level of PPARy was detected with immunohistochemistry in the glioma from 48 cases with glioma. The progression-free survival and overall survival were compared with Kaplan-Meier survival curve between the patients with more expression of PPARy and less ones. Results The expression of PPARy decreased （P〈0.01） with the the tumor malignancy increasing from grade I to IV, which was negatively correlated （1=-0.770, P〈0.01）. Both the progression-free and overall survival time were significant dif- ference between the patients with more expression of PPARγ and less ones （P〈0.01）. Conclusion PPARγ expression correlates with the ma- lignancy of human glioma, which may predict the outcome of the patients.

关 键 词：神经胶质瘤 过氧化物酶体增殖物激活受体Γ 免疫组织化学 预后 

分 类 号：R730.264[医药卫生—肿瘤]