神经节苷酯联合高压氧治疗小儿痉挛型脑瘫  

Effect of Ganglioside Combined with Hyperbaric Oxygen on Spastic Cerebral Palsy

作　　者：林志[1] 陈慧[1] 李红刚[2] 杨芳[1] 

机构地区：[1]福建省立医院儿科,福建福州市350001 [2]中国人民解放军第四七六医院脑瘫中心,福建福州市350002

出　　处：《中国康复理论与实践》2013年第3期255-256,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨神经节苷酯联合高压氧治疗小儿痉挛型脑瘫的临床效果。方法128例痉挛型脑瘫患儿分为神经节苷酯联合高压氧治疗的治疗组（n=70）和胞二磷胆碱治疗的对照组（n=58），治疗组根椐年龄大小分为6～12个月组（n=38）和1～3岁组（n=32）。治疗前后采用Ashworth量表、功能独立性测量（FIM）进行评定。结果治疗组治疗后Ashworth量表、FIM评分均明显优于对照组（P〈0．01）；治疗组中6-12个月组明显优于1～3岁组（P〈0．01）。结论神经节苷酯联钠联合高压氧治疗能改善痉挛型脑瘫患儿肌张力与日常生活活动能力。年龄越小，效果越好。Objective To investigate the effect of combination of ganglioside and hyperbaric oxygen on spastic cerebral palsy. Methods 128 infants with spastic cerebral palsy were divided into treatment group （n=70） and control group （n=58）, who received ganglioside and hy- perbaric oxygen or cytidine diphosphate choline. The infants in the treatment group were divided into young group （6-12 months, n=38） and old group （1-3 years, n=32） according to their age. They were assessed with Ashworth scale and Functional Independence Measure （FIM） before and 3 courses after treatment. Results The scores of Ashworth scale and FIM improved more in the treatment group than in the con- trol group （P〈0.01） after treatment, as well as in the young group than in the old group （P〈0.01）. Conclusion The combination of ganglio- side and hyperbaric oxygen is effective on spasticity and activities of daily living in infants with spastic cerebral palsy. The younger the in- fants are, the more effective it is.

关 键 词：痉挛型脑瘫 神经节苷酯 高压氧 幼儿 

分 类 号：R742.3[医药卫生—神经病学与精神病学]