神经节苷脂治疗中重度HIE的近期疗效观察  

作　　者：林建华[1] 施聪耐 

机构地区：[1]浙江省绍兴第二医院儿科,312000 [2]浙江省绍兴县卫生进修学校,312000

出　　处：《浙江临床医学》2013年第4期469-471,共3页Zhejiang Clinical Medical Journal

摘　　要：目的探讨神经节苷脂治疗新生儿缺氧缺血性脑病（HIE）的临床疗效.方法选取HIE患儿80例,随机分为观察组和对照组,各40例.两组患儿均给予常规及对症支持治疗,观察组加用神经节苷脂,对照组加用胞二磷胆碱.观察临床治疗效果.结果观察组患儿总有效率92.50%,明显高于对照组的75.00%（P〈0.05）.治疗2周和4周后,两组患者NBNA评分较治疗前均提高（P〈0.05）,观察组提高更显著（P〈0.05）.结论在常规治疗基础上加用神经节苷脂治疗中重度HIE,可以显著改善患儿临床症状,促进受损神经功能恢复,提高疗效.Objective To investigate the clinical therapeutic effects of ganglioside on hypoxic-ischemic encephalopathy （HIE）. Methods 80 sick children meeting the criteria were selected and randomly divided into observation group and control group,40 children each group; based on routine,symptomatic and supporting treatments;the observation group was supplemented with ganglioside,while the control group supplemented with cytidine diphosphate choline,and the clinical therapeutic effects were observed. Results The total effective rate of the observation group was 92.50%,significantly higher than that of the control group（75.00%）,and the difference was statistically significant（P〈0.05）. The difference in pretherapy NBNA score between the two groups had no statistic significance（P〉0.05）;in 2 weeks and 4 weeks after the treatments,the NBNA scores of both groups were higher than those before the treatments（P〈0.05）,but the NBNA scores of the observation group were increased more significantly（P〈0.05）. Conclusion Routine treatment supplemented with ganglioside in treatment of moderate and severe HIE can significantly improve the clinical symptoms,promote recovery of damaged nerve functions and elevate clinical therapeutic effects,and consequently is worthy of clinical generalization and application.

关 键 词：新生儿 缺血缺氧性脑病 神经节苷脂 新生儿行为神经 

分 类 号：R734.2[医药卫生—肿瘤]