京尼平苷四种不同给药途径的肝毒性初步研究  

Preliminary Studies on Liver Toxicity of Gardenoside with Four Different Pathways of Administration

作　　者：王智勇[1] 张海燕[2,3] 杨明[3,4] 高龙潭[1] 芦乾[3] 宋伟[3] 刘昊[3] 汪建民[1] 

机构地区：[1]江西中医学院基础医学院,江西南昌330004 [2]西南交通大学材料先进技术教育部重点实验室,四川成都610003 [3]江西中医学院现代中药制剂教育部重点实验室,江西南昌330004 [4]成都中医药大学,四川成都611137

出　　处：《现代生物医学进展》2013年第5期824-827,共4页Progress in Modern Biomedicine

基　　金：国家科技重大专项--脑靶向神经修复中药-栀子鼻腔喷雾剂研究(2009ZX09103-393)

摘　　要：目的:依据临床的几种常规的给药方式,对比研究京尼平苷不同给药途径对肝脏的毒性作用,为其进一步研究开发及临床应用提供依据。方法:应用SD大鼠,采用口服(ig)、静注(iv)、肌注(im)、鼻腔(ns)四种给药途径给予京尼平苷溶液一个月。以肝脏指数、丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)为指标,考察不同给药途径下京尼平苷的肝脏毒性作用。结果:由肝脏指数得出:口服(ig)>静注(iv)>鼻腔(ns)≈肌注(im)>空白(P<0.05);由血清丙氨酸氨基转移酶(ALT)及天冬氨酸氨基转移酶(AST)的活性得出:静注(iv)>口服(ig)>肌注(im)>鼻腔(ns)>空白(P<0.01)。结论:综合上述指标分析,口服(ig)、静注(iv)、肌注(im)、鼻腔(ns)四种给药途径中,鼻腔(ns)给药方式的京尼平苷对肝脏的毒性作用较小。Objective： To study the liver toxicity of gardenoside with four different pathways of administration in rats,to provide more information for the further research and clinical application.Methods： The SD rats were used and randomly divided into five groups,including blank group,oral group（ig）,intravenous injection group（iv）,muscles injection group（im）,nasal group（ns）.Gardenoside solution was repeated doses for one month.Then the rats were died,and we studied the liver toxicity of gardenoside with liver index,alanine aminotransferase and aspartate aminotransferase for index.Results： According to the liver index,the liver toxicity of gardenoside was igivns≈imblank group（P0.05）;according to the alanine aminotransferase and aspartate aminotransferase,the liver toxicity of gardenoside was ivigimnsblank group（P0.01）.Conclusion： Among the four pathways of administration of gardnoside,nasal（ns） was the best route,which has fewer liver toxicity than others.

关 键 词：京尼平苷 给药途径 肝毒性 肝脏指数 血清丙氨酸氨基转移酶 天冬氨酸氨基转移酶 

分 类 号：Q95-3[生物学—动物学] R574.8[医药卫生—消化系统]