弹性成像定量分析技术在肝纤维化分期中的作用研究  

Function of Real-time Tissue Eastography with Qantitative Analysis for Saging Liver Fibrosis

作　　者：周艳贤[1] 郭晓东[1] 董政[1] 陈敏[1] 冯卉[1] 董晓宇[1] 

机构地区：[1]解放军302医院,北京100039

出　　处：《现代生物医学进展》2013年第4期671-673,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨实时组织弹性成像技术(RTE)的弹性特征量以及弹性评分在慢性乙型病毒性肝炎(乙肝)肝纤维化的分期诊断中的价值。方法:应用RTE检测对140例慢性乙肝患者进行肝脏的弹性评分,测定肝组织弹性特征量:平均相对应变:(Mean)、相对应变值的标准差(SD)、求解面积中蓝色所占百分比(%Area)、蓝色区混杂其他颜色程度(Comp),并与肝穿刺活检的病理分期相对照。结果:在RTE肝脏弹性评分中,阳性者112例,阴性28例,RTE弹性评分在肝纤维化定性诊断中的敏感度与特异度分别为96.26%与72.73%。Mean、SD、%Area、Comp与病理诊断相关较好(Mean:r=-0.838,P<0.05;%Area:r=0.864,P<0.05),且弹性评分较常规超声在灵敏度(RTE:96.26%VS常规:64.49%)及特异度(RTE:72.73%VS常规:33.33%)更高。结论:RTE为评价肝纤维化程度的提供了新方法,是对肝纤维化诊断手段提供了新的补充。Objective： To evaluate the values of liver fibrosis staging of chronic hepatitis B by elastic characteristic quantities and the elasticity ratings in Real-time Tissue Elastography（RTE）.Methods： The liver elasticity ratings of 140 patients with chronic hepatitis B patients were detected by RTE.The liver tissue elasticity characteristics： The average relative strain（Mean）,the standard deviation of relative strain value（SD）,the percentage of blue in solving area（%Area）,the degrees of Blue area mixed with other colors（Comp） were determined and compared with liver biopsy pathological staging.Results： There were positive 112 cases and negative 28 cases in the liver elasticity ratings.The sensitivity and specificity of the qualitative diagnosis of liver fibrosis by RTE elasticity ratings were 96.26% and 72.73%,respectively.The correlations of Mean,SD,% Area and Comp contrast with pathological diagnosis were better than those in the conventional ultrasound（Mean： r=-0.838,P0.05;%,Area： r=0.864,P0.05）.The sensitivity（RTE： 96.26% VS conventional： 64.49%）and specificity（RTE： 72.73% VS conventional： 33.33%）in the elastic ratings were much higher than those in the conventional ultrasound.Conclusion： RTE provides a new method for the evaluation of liver fibrosis,gave the liver fibrosis diagnosis means a new supplement.

关 键 词：肝纤维化 实时组织弹性成像技术 肝组织弹性评分 

分 类 号：R575.2[医药卫生—消化系统] R445.1[医药卫生—内科学]