斯钙素-1基因在食管鳞癌患者骨髓中的检测及其临床意义  

Clinical Significance of Stanniocalcin-1 mRNA Detection in Bone Marrow of Esophageal Squamous Cell Carcinoma Patients

作　　者：宋海珠[1] 潘半舟[1] 熊磊[2] 许飚[2] 叶杰 易俊[2] 

机构地区：[1]南京军区南京总医院肿瘤内科,江苏南京210002 [2]南京军区南京总医院心胸外科,江苏南京210002 [3]南京军区空军司令部门诊部内一科,江苏南京210002

出　　处：《现代生物医学进展》2013年第4期674-677,共4页Progress in Modern Biomedicine

基　　金：江苏省自然科学基金项目(BK2012371)

摘　　要：目的:探讨斯钙素(stanniocalcin-1,STC-1)在食管鳞癌(Esophageal squamous cell carcinoma,ESCC)患者骨髓中的表达及其临床意义。方法:术中收集85例ESCC患者肋骨骨髓,应用巢式RT-PCR检测STC-1 mRNA的表达,并分析其与临床病理特征及两年无进展生存(Progress Free Survival,PFS)的关系。结果:骨髓STC-1 mRNA阳性率为21.2%(18/85)。STC-1阳性与患者临床分期(P=0.013)及淋巴结转移(P=0.029)相关,其2年PFS(平均15.0月)亦劣于STC-1阴性者(平均19.7月)(P=0.003)。结论:骨髓STC-1 mRNA检测对于判断ESCC微转移具有重要意义,可望成为ESCC潜在预后标志物。Objective： To study the clinical significance of the marker of disseminated tumor cells,stanniocalcin-1（STC-1） expression in bone marrow（BM） of esophageal squamous cell carcinoma patients.Methods： STC-1 mRNA expression was determined using nest RT-PCR in BM of 85 ESCC patients,and its associations with clinicopathological factors and 2 year progress free survival（PFS） were further evaluated.Results： The positive expression of STC-1 mRNA in BM was 21.2%（18/85）.Furthermore,STC-1 mRNA expression in BM was associated with the advanced stage（P=0.013）,lymph metastasis（P=0.029） and adverse 2-year PFS（mean 15.0 months vs 19.7 months,P=0.003）.Conclusions： STC-1 mRNA detection in BM was useful to evaluate micrometastasis of ESCC,which may be a potential biomarker for prognosis assessment of ESCC.

关 键 词：食管癌 斯钙素-1 骨髓 预后 

分 类 号：R735.1[医药卫生—肿瘤]