MicroRNA在调控物质代谢方面的作用  

MicroRNA and metabolism regulation

作　　者：李明[1] 谢慧清[1] 熊武[1] 徐丹[1] 曹科[1] 刘睿[1] 周建大[1] 罗成群[1] 

机构地区：[1]中南大学湘雅三医院整形外科,长沙410013

出　　处：《中南大学学报（医学版）》2013年第3期318-322,共5页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81272192;81071645);湖南省自然科学基金(10JJ3030);湖南省卫生厅科研基金(B2010031)~~

摘　　要：MicroRNA通过干预靶基因表达水平构建了复杂的调控网络,调控生命活动的进行。目前已发现microRNA广泛参与葡萄糖、脂类、氨基酸的代谢及生物氧化过程,在一些重要位点上发挥调控作用。在人体摄取和利用葡萄糖过程中,microRNA参与调控胰岛素分泌、胰岛素敏感性、细胞对葡萄糖摄取、细胞内糖酵解途径等,并可影响线粒体功能及有氧氧化。在脂类代谢中,microRNA作用于脂类合成、分解及转运相关的靶基因,调控体内脂类代谢。此外,microRNA还与谷氨酰胺异化代谢有关。MicroRNAs have been identified as a new class of regulatory molecules that affect many biological funtions by interferring the target gene expressions. Latest studies demostrate that microRNAs can influence many pivotal bio-processes and deeply involve in the metabolism of glucose, lipid and amino acid and biological oxidation. For glucose metabolism, microRNAs are related to insulin secretion, insulin sensitivity, glucose uptake, glycolysis, oxidation and mitochondrial function. For lipid matebolism, microRNAs can regulate the target genes related to lipid biosynthesis, catabolism and transportation. MicroRNAs can influence glutamine catabolism.

关 键 词：微小RNA 代谢 胰岛素 糖酵解 线粒体 脂肪 氨基酸 

分 类 号：R363[医药卫生—病理学]