NK／T细胞淋巴瘤发病机制研究进展  

Research progress in the pathogenesis of NK/T-cell lymphoma

作　　者：黄小银[1] 王靖华[1] 

机构地区：[1]南京大学医学院临床学院,南京军区南京总医院肿瘤内科,南京市210002

出　　处：《中国肿瘤临床》2013年第6期367-370,共4页Chinese Journal of Clinical Oncology

摘　　要：NK/T细胞淋巴瘤(NK/T cell lymphoma,NKTCL)属高度侵袭性肿瘤,预后差,目前尚无明确有效的治疗方案。除了组织形态改变及EBV相关,该病也存在染色体异常、基因突变、信号通路及蛋白表达的异常。国内外学者由此出发,对其发病机制进行了持续的深入研究。本文就NKTCL发病机制的研究进展作一综述。NK/T-cell lymphoma has a poor prognosis because of the invasiveness of this disease. No etlcctive treatments exist br this condition. Aside from causing histologic and EBV-related changes, the disease also causes chromosome abnormality, gene mutation, and abnormality in the signal pathway and protein expression. Thus, many domestic and international scholars have conducted sustainable in-depth studies on the pathogenesis of the tumor. This paper summarizes the research progress on the pathogenesis ofNK/T-cell lymphoma.

关 键 词：NK T细胞淋巴瘤EBV基因突变信号通路 

分 类 号：R733.1[医药卫生—肿瘤]