急性白血病患者血清乳酸脱氢酶与α羟丁酸脱氢酶水平的临床意义  

Clinical significance of serum lactic dehydrogenase and α-hydroxybutyrate dehydrogenase in patients with acute leukemia

作　　者：徐数娜[1] 张旭辉[1] 张日[1] 

机构地区：[1]苏州大学附属第一医院血液病科,江苏省215000

出　　处：《江苏医药》2013年第7期819-821,共3页Jiangsu Medical Journal

摘　　要：目的探讨急性白血病(AL)血清乳酸脱氢酶(LDH)与α羟丁酸脱氢酶(α-HBDH)的临床价值。方法初诊AL患者231例(A组)中,143例为完全缓解(A1组),31例出现缓解后复发(A2组),A组根据白细胞数分为高白细胞(C1)组、白细胞正常(C2)组和低白细胞(C3)组。另设正常人群101例作为对照(B组)。采用酶学法检测各组血清LDH和α-HBDH水平。结果 A组血清LDH和α-HBDH浓度为604.6U/L和455.59U/L,明显高于B组的194.93U/L和144.48U/L(P<0.05);A2组血清LDH和α-HBDH浓度为390.46U/L和282.12U/L,明显高于B组和A1组的221.25U/L和163.76U/L(P<0.05)。C1组血清LDH和α-HBDH浓度为785.83U/L和584.26U/L,明显高于C2组的466.17U/L和363.41U/L和C3组的318.43U/L和246.5U/L(P<0.05)。A组中,急性淋巴细胞白血病患者的血清LDH和α-HBDH浓度为992.01U/L和757.33U/L,明显高于急性髓细胞白血病患者的497.66U/L和372.44U/L(P<0.05)。结论血清LDH和α-HBDH可作为AL诊治过程中判断病情变化和预测复发的参考指标。Objective To investigate the clinical significance of serum lactic dehydrogenase （LDH） and α-hydroxybutyrate dehydrogenase （α-HBDH） in the patients with acute leukemia （AL）. Methods Of 231 newly diagnosed AL patients（group A）, 143 cases were with complete remission （group A1）, 31 cases with relapsed（group A2）, Group A was divided into high leukocyte（group C1）, normal leukocyte（group （32） and low leukocyte group（C3）. One hundred and one healthy people were taken as the controls（group B）. Serum LDH and α-HBDH were measured using enzymatie methods. Results The median values of serum of LDH and α-HBDH in group A were 604, 6 U/L and 455.59 U/L,respectively,which were higher than 194. 93 U/L and 144. 48 U/L in group B（P〈0. 05）, Serum LDH and α-HBDH in group A2 were 390. 46 U/L and 282.12 U/L,which were higher than those in group B and 221.25 U/L and 163.76 U/L in group AI（P〈0. 05）, Serum LDH and α-HBDH in group C1 were 785.83 U/L and 584. 26 U/L,which were higher than 466.17 U/L and 363, 41 U/L in group （22 and 318. 43 U/L and 246.5 U/L in group C3（P〈0, 05）. In group A,serum LDH and α-HBDH in the cases with acute lymphoblastic leukemia were 992. 01 U/L and 757. 33 U/L, which were higher than 497.66 U/L and 372. 44 U/L in those with acute myeloid leukemia （P〈0. 05）. Conclusion Serum levels of LDH and α-HBDH can be considered as the indicators for evaluating theraputic outcome and Dredictinz the prognosis in the treatment of patients with AL.

关 键 词：急性白血病 乳酸脱氢酶 α羟丁酸脱氢酶 

分 类 号：R733[医药卫生—肿瘤]