胃肠道间质瘤靶向治疗的影像学评价与检查规范  

Examination standards and radiological evaluation of targeted therapy for gastrointestinal stromal tumor~

作　　者：张晓鹏[1] 

机构地区：[1]北京大学肿瘤医院医学影像科、北京市肿瘤防治研究所,100142

出　　处：《中华消化外科杂志》2013年第4期257-261,共5页Chinese Journal of Digestive Surgery

基　　金：国家“973”重点基础研究发展计划项目（2006CB705706）;国家自然科学基金（81201215）;首都临床特色应用研究项目（Z121107001012115）

摘　　要：传统形态学标准难以准确反映胃肠道间质瘤（GIST）靶向治疗后的病理组织学改变，已无法满足个体化诊断治疗时代对影像学评价手段的需求。Choi标准及后续多个CT检查联合标准的出现，为客观反映GIST靶向治疗后的组织学改变提供了新的标准。PET-标准摄取值和MRI扩散加权成像表观扩散系数值的变化，可从功能成像角度反映GIST靶向治疗后的早期组织学改变，为其疗效评价提供新的有潜力指标。制订并遵循规范的影像学检查及评价流程，有利于GIST个体化诊断治疗的开展。Conventional morphological evaluation criteria cannot objectively reflect the histopathological changes of gastrointestinal stromal tumor （GIST） to targeted therapy, and therefore it is unable to adapt to the requirements of the development of personalized medicine. The emerging of Choi and subsequent joint criteria of computed tomography diagnosis provides new methods for the evaluation of the histopathological changes of GIST to targeted therapy. Positron emission tomography （PET）-standardized uptake value （SUV） and apparent diffusion coefficient （ADC） on diffusion-weighted magnetic resonance im- aging （MRI） can reflect the histopathologieal changes of GIST to targeted therapy in the early stage through functional imaging, and provide new potential biomarkers for evaluating the efficacy. Standardized radiological examination and evaluation process are conducive to launch the personalized treatment of GIST.

关 键 词：胃肠道间质肿瘤 CT检查 磁共振成像 扩散加权 疗效评价 

分 类 号：R735[医药卫生—肿瘤]