肺癌组织表皮生长因子受体与RAS/MARK信号通路活化蛋白ERK1/2表达的相关性及其临床意义  

Roles of EGFR and RAS/MAPK signal transduction pathway activated protein ERK1/2in lung cancer

作　　者：李龙[1] 张红 唐发兵[3] 杨兰生[3] 

机构地区：[1]兰州大学第一医院呼吸科,甘肃兰州730000 [2]甘肃省第二人民医院急诊科,甘肃兰州730000 [3]兰州大学第一医院病理科,甘肃兰州730000

出　　处：《东南大学学报（医学版）》2013年第2期218-221,共4页Journal of Southeast University(Medical Science Edition)

摘　　要：目的:通过观察表皮生长因子受体(EGFR)、RAS/MAPK信号通路活化蛋白ERK1/2在肺癌组织中的表达情况,探讨EGFR与ERK1/2的相关性及其在肺癌发病机制中的可能作用。方法:选用胸外科手术切除和经纤维支气管镜获取的肺组织标本86份,通过免疫组化S-P法检测EGFR、ERK1/2在正常组织和恶变组织细胞中的表达。结果:肺癌、肺癌外周组织中EGFR、ERK1/2阳性表达率均显著高于正常组织(P<0.01),且EGFR与非小细胞肺癌关系密切(P<0.01),EGFR与ERK1/2有显著相关性(r=0.551)。结论:EGFR、ERK1/2在肺癌组织中高表达,提示在肺癌的发生、发展中起到重要作用,对其的研究可为肺癌的防治提供理论依据。Objective： To study the expression of epidermal growth factor receptor（EGFR） and RAS/MAPK signal transduction pathway activated protein ERK1/2 in pulmonary tissues and investigate its value for the development of lung cancer.Methods： The expression of EGFR and ERK1/2 in 86 pulmonary tissues obtained through thoracic operation and bronchoscopy were examined by S-P immunohistochemical technique.Results： The positive rate of EGFR and RAS/MAPK signal transduction pathway activated protein ERK1/2 in the lung cancer cases were significantly higher than that in control cases（P〈0.01）. The expression of EGFR in the non-small cell lung cancer cases was significantly higher than that in small cell lung cancer cases（P〈0.01）.There was an certain relativity between EGFR and ERK1/2（r=0.551）.Conclusion： EGFR and ERK1/2 play an important role in the occurrence and development of lung cancer.

关 键 词：表皮生长因子受体 ERK1 2 肺癌 表达 

分 类 号：R734.2[医药卫生—肿瘤]