癌基因蛋白c-myc、c-myb、c-erbB-2在乳腺癌组织中的表达  

Expression of c-myc, c-myb and c-erbB-2 protein in breast cancer

作　　者：刘德纯[1] 赵云霞[2] 

机构地区：[1]厦门大学附属成功医院解放军一七四医院病理科,福建厦门361003 [2]蚌埠医学院病理生理学教研室,福建厦门361003

出　　处：《中国基层医药》2013年第5期641-643,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：安徽省教育厅自然科学研究资助项目（2004kj277）

摘　　要：目的探讨c-myc、c-myb及c-erbB-2基因蛋白的异常表达在乳腺癌发生发展中的作用及其临床意义。方法应用免疫组织化学S-P法检测c-myc、c-myb及c-erbB-2基因蛋白在150例乳腺癌标本及30例乳腺良性增生性病变中的表达，并对其与临床病理指标的关系进行相关性分析。结果乳腺癌组c-myc、c-myb和c-erbB-2基因蛋白的阳性表达率均高于良性增生性病变组（均P〈0．05）。c-myc的表达与乳腺癌组织学分级、淋巴结转移及病理类型有相关性（均P〈0．05）。c-myb的表达与乳腺癌组织学分级相关（P〈0．05）。c-erbB-2的表达与乳腺癌的大小、分级和PR表达相关（均P〈0．05）。3种基因蛋白的表达具有相关性。结论c-myc、c-myb和c-erbB-2基因蛋白在乳腺良性增生性病变中已有一定程度的表达，在乳腺癌中表达率明显增高，并差异有统计学意义，均与乳腺癌的分级相关，分别与肿瘤大小、病理类型、PR表达和淋巴结转移等预后指标也有一定关系，表明其在肿瘤的发生发展中被激活，引起细胞生长与增殖。它们的阳性表达可作为预后指标。Objective To investigate the roles of aberrant expression oi c-myc, c-myb, and c-erbtB-z m me development of breast cancer and its clinical significance. Methods Immunohistochimical technique （ S-P method） was used to detect the expression of c-myb, c-myc and c-erbB-2 protein in 150 cases of breast cancer and 30 cases of benign proliferative lesions, heir relation to clinical pathological parameters were analyzed. Results The protein ex- pression levels of c-myc, c-myb, and c-erbB-2 in breast cancer were higher than those in benign proliferative lesions and the difference was significant（ all P 〈 0.05 ）. Expression of c-myc protein had obvious relationship to histological grade ,lymph nodes metastasis and pathological types（ all P 〈 0.05 ）. Expression of c-myb protein related significantly to histological grade （ P 〈 0.05 ）. c-erbB-2 was associated with the tumor size, grading, PR expression （ all P 〈 0.05 ）. The association among the three kinds of genetic proteins was observed. Conclusion Expressions of oncogenes c- myc, c-myb, and c-erbB-2 proteins are higher in breast cancer and lower in benign proliferative lesions. The difference is significant. They are related to the grading and some other prognostic factors such as tumor size, pathologic types, PR expression and lymph node metastasis. The results suggest that these oncogenes are activated in the development of breast cancer and provoke cancerous cells multiplication. Expressions of oncogenes c-myc, c-myb and c-erbB-2 might be considered to be the prognostic indicators of breast cancer.

关 键 词：乳腺癌 C-MYC C-MYB C-ERBB-2 病理学 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]