落花生茎叶醋酸乙酯部位化学成分研究  

Chemical constituents from ethyl acetate fraction in stems and leaves of Arachis hypogaea

作　　者：杨杰[1] 纪瑞峰[2] 王丽莉[3,4,5,6] 张铁军[3,4,5,6] 

机构地区：[1]天津医科大学,天津300070 [2]天津中医药大学,天津300193 [3]天津药物研究院,天津300193 [4]天津市中药质量控制技术工程实验室,天津300193 [5]中药现代制剂与质量控制技术国家地方联合工程实验室(天津),天津300193 [6]释药技术与药代动力学国家重点实验室,天津300193

出　　处：《现代药物与临床》2013年第2期147-149,共3页Drugs & Clinic

摘　　要：目的研究落花生Arachis hypogaea茎叶的化学成分。方法采用硅胶柱色谱、凝胶柱色谱和ODS柱色谱进行分离纯化,通过理化方法和波谱数据进行结构鉴定。结果从落花生茎叶70%乙醇提取液的醋酸乙酯萃取部位分离得到8个化合物,经波谱分析鉴定其结构,分别为肉豆蔻酸(1)、十五碳酸(2)、汉黄芩素(3)、美迪紫檀素(4)、邻苯二甲酸二丁酯(5)、异香草酸(6)、芒柄花素(7)、β-谷甾醇(8)。结论化合物2、3、4、5、7为首次从该植物中分离得到。Objective To study the chemical constituents in the stems and leaves of Arachis hypogaea.Methods The compounds were isolated and purified by silica gel column chromatography,gel chromatography,and ODS column chromatography.Their structures were elucidated by chemical and spectral analyses.Results Eight compounds were obtained from the ethyl acetate fraction of 70% ethanol extraction in the stems and leaves of A.hypogaea and their structures were identified as myristic acid（1）,pentadecanoic acid（2）,wogonin（3）,medicarpin（4）,dibutyl phthalate（5）,isovanillic acid（6）,formononetin（7）,and β-sitosterol（8）.Conclusion Compounds 2,3,4,5,and 7 are isolated from this plant for the first time.

关 键 词：落花生 十五碳酸 汉黄芩素 邻苯二甲酸二丁酯 芒柄花素 

分 类 号：R284.1[医药卫生—中药学]