血清血管内皮生长因子在儿童肾母细胞瘤中的表达及临床意义  

Expression and clinical significance of serum vascular endothelial growth factor in children with Wilms tumor

作　　者：范秋霞[1] 

机构地区：[1]河南省商丘市第一人民医院儿科,476100

出　　处：《中国医师进修杂志》2013年第9期36-38,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨血清血管内皮生长因子（VEGF）在儿童肾母细胞瘤中的表达，阐明VEGF在肾母细胞瘤侵袭和进展中的作用。方法回顾性分析手术治疗的30例肾母细胞瘤患儿（肾母细胞瘤组）的临床资料，并选择因感冒发热症状就诊的患儿30例作为对照组，采用酶联免疫吸附法测定两组患儿血清VEGF水平。结果肾母细胞瘤组患儿血清VEGF水平为（567．90±189．30）ng／L，对照组为（55．46±18．49）ng／L，肾母细胞瘤组显著高于对照组（t=14．757，P〈0．05）。VEGF的表达与患儿的NWTS分期、预后组织分型和淋巴结转移有相关性（P〈0．01）。NWTSⅢ-Ⅳ期、有淋巴结转移、预后组织分型不良的肾母细胞瘤患儿血清VEGF水平明显高于NWTSⅠ～Ⅱ期、无淋巴结转移、预后组织分型良好的肾母细胞瘤患儿（P〈0．01）。结论血清VEGF水平在儿童肾母细胞瘤中呈高表达，肾母细胞瘤患儿血清VEGF水平与NWTS分期、预后组织分型和淋巴结转移有关，高水平的VEGF提示肾母细胞瘤的侵袭和进展，患儿预后不良。Objective To investigate the expression of serum vascular endothelial growth factor （VEGF） in children with Wihns tumor,and clarify the effect of VEGF in the invasion and progression of Wilms tumor. Methods Thirty children with Wilms tumor who underwent surgical treatment were retrospectively analyzed as Wilms tumor group, the control group was 30 children who underwent treatment by cold and fever symptoms. The serum VEGF levels of 2 groups were detected by enzyme-linked immunosorbent assay. Results The serum VEGF level of Wilms tumor group was significantly higher than that of control group [（567.90 ± 189.30） ng/L vs. （55.46 ±18.49） ng/L,t = 14.757,P 〈0.05]. The expression of serum VEGF was closely related to NWTS stage, prognosis tissue type and lymph node metastasis （P 〈 0.01 ）. The expressions of serum VEGF in the NWTS Ⅲ- Ⅳ stage,lymph node metastasis and poor prognosis tissue type Wilms tumor were significantly higher than those of NWTS Ⅰ - Ⅱ stage, without lymph node metastasis, good prognosis tissue type Wilms tumor （P 〈 0.01 ）. Conclusions The expression of serum VEGF is high in children with Wilms tumor,the serum VEGF level is closely related to NWTS stage, prognosis tissue type and lymph node metastasis. The high expression of serum VEGF shows the invasion, progression and poor prognosis in children with Wilms tumor.

关 键 词：血管内皮生长因子类 WILMS瘤 儿童 血清 

分 类 号：R737.11[医药卫生—肿瘤]