Synthesis and Characterization of pH-Responsive Block Copolymers with Primary Amine Groups  

作　　者：WANG Hong ZHU Yue-jun REN Xiao-na ZHANG Hong TAN Ye-bang 

机构地区：[1]Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China [2]State Key Laboratory of Offshore Oil Exploitation, Technology Research Department of Research Center, China National Offshore Oil Corporation, Beijing 100027, P, R. China

出　　处：《Chemical Research in Chinese Universities》2013年第2期389-395,共7页高等学校化学研究（英文版）

基　　金：Supported by the National Basic Research Program of China（No.2009CB930103） and the Natural Science Foundation of Shandong Province of China（No.ZR2011BM002）.

摘　　要：A new pH-responsive block copolymer, methoxy poly（ethylene glycol）-b-poly[5-methacrylamido- pentylamine hydrochloride]（mPEG-b-PMAAPA） was synthesized and characterized in this paper. The monomer 5-methacrylamido-pentylamine hydrochloride（MAAPA） and the macroinitiator（mPEG-ACVA） were synthesized, re- spectively, and mPEG-b-PMAAPA was then obtained by free radical polymerization. The structure and molecular weight of mPEG-b-PMAAPA were cont]rmed by hydrogen nuclear magnetic resonance（~H NMR） spectroscopy and gel permeation chromatography with multiangle laser light scattering（GPC-MALLS） measurements. At a low pH, it is hydrophilic due to the protonation of the primary amine groups. With increasing pH value, deprotonation occurs and the hydrophobicity of PMAAPA block increases. This molecular feature leads to interesting aggregation behavior of mPEG-b-PMAAPA in aqueous solutions at different pH values as revealed by dynamic light scattering（DLS） measurements, transmission electron microscopy（TEM） observations and resonance light scattering（RLS） measure- ments.A new pH-responsive block copolymer, methoxy poly（ethylene glycol）-b-poly[5-methacrylamido- pentylamine hydrochloride]（mPEG-b-PMAAPA） was synthesized and characterized in this paper. The monomer 5-methacrylamido-pentylamine hydrochloride（MAAPA） and the macroinitiator（mPEG-ACVA） were synthesized, re- spectively, and mPEG-b-PMAAPA was then obtained by free radical polymerization. The structure and molecular weight of mPEG-b-PMAAPA were cont]rmed by hydrogen nuclear magnetic resonance（~H NMR） spectroscopy and gel permeation chromatography with multiangle laser light scattering（GPC-MALLS） measurements. At a low pH, it is hydrophilic due to the protonation of the primary amine groups. With increasing pH value, deprotonation occurs and the hydrophobicity of PMAAPA block increases. This molecular feature leads to interesting aggregation behavior of mPEG-b-PMAAPA in aqueous solutions at different pH values as revealed by dynamic light scattering（DLS） measurements, transmission electron microscopy（TEM） observations and resonance light scattering（RLS） measure- ments.

关 键 词：Block copolymer POLYAMINE PH-RESPONSIVE Water soluble copolymer 

分 类 号：O631.1[理学—高分子化学] TB324[理学—化学]