晶状体细胞膜流动性与白内障发病机制的相关研究  

Studies on fluidity of lens cell membrane and pathogenesis of cataract

作　　者：竺向佳[1] 张可可[1] 卢奕[1] 

机构地区：[1]复旦大学附属眼耳鼻喉科医院眼科,上海200031

出　　处：《国际眼科纵览》2013年第1期19-24,共6页International Review of Ophthalmology

基　　金：国家自然科学基金青年基金项目（81100653）

摘　　要：从流动镶嵌模型到脂筏，细胞膜的结构模型研究不断进展。细胞膜的流动性是指构成细胞膜的脂质和蛋白质分子的运动性。对细胞膜流动性的观察方法包括自旋标记电子顺磁共振和荧光探针等。某些可溶性蛋白与细胞膜的相互作用，能改变其流动性。目前对于晶状体细胞膜流动性的研究十分有限，其脂质构成的特殊性，暗示了晶状体细胞膜流动性的特殊性。随年龄增长，晶状体核区细胞间弥散途径的建立，合胞体超结构的形成，可能需要其细胞膜流动性发生相应改变。以晶状体细胞膜流动性研究为切入点，有助于深入阐明白内障的发病机制。（国际眼科纵览，2013，37：19—24）From the fluid mosaic model to lipid rafts, the structural model of the cell membrane has been updating continuously. The cell membrane fluidity refers to the movement of lipid and protein molecules that construct the cell membrane together. Nowadays, there are several methods of fluidity observation through different mechanisms, such as spin labeling electron paramagnetic resonance and various fluorescent probes. The interaction of certain soluble proteins with the cell membrane can also alter its fluidity and other properties. For the lens cell membrane, there has been only limited research on its fluidity. The particular composition of lipids in lens cell membrane implies the special nature of its fluidity. As age is increasing, the fluidity of lens membrane changes accordingly, leading to the establishment of the diffusion pathways a- mong the cells in the nuclear region, and the formation of syncytial uhrastructure. The analysis of the fluidity of lens cell membrane will be helpful in the future for further clarifying the pathogenesis of cataract. （ Int Rev Ophthalmol, 2013, 37： 19-24）

关 键 词：细胞膜流动性 6-酰基-2-二甲酰氨基萘 总极化值 α晶状体蛋白 晶状体 

分 类 号：R776.1[医药卫生—眼科]