响应面法优化辛烯基琥珀酸淀粉酯-莪术油乳液的乳化工艺研究  

Research on Response Surface Analysis Optimizing Emulsification of Starch Sodium Octenyl Succinate (SSOS)-Zedoary Oil

作　　者：王亮[1,2] 吕国军[1] 廖翰[1] 赵姗[1] 吕岩[1,2] 刘袖洞[1] 马小军[1] 

机构地区：[1]中国科学院大连化学物理研究所,大连116023 [2]中国科学院研究生院,北京100049

出　　处：《世界中医药》2013年第3期329-331,共3页World Chinese Medicine

摘　　要：目的:采用响应面法优化高取代度的辛烯基琥珀酸淀粉酯(SSOS)-莪术油乳液的乳化工艺。方法:采用高效液相色谱法测定不同取代度、糊液浓度、芯壁比对SSOS-莪术油乳液中莪术醇和β-榄香稀包封率的影响,并在单因素试验的基础上,利用响应面法对乳化条件进行优化。正交试验考察乳液稳定性。结果:响应面法分析结果表明:最优乳化条件为SSOS取代度0.07,乳液浓度0.05,芯壁比0.17。在此工艺条件下,莪术醇的包封率为100.00%,β-榄香稀的包封率为34.891%。结论:响应面法对辛烯基琥珀酸淀粉酯-莪术油乳液的乳化工艺具有实际指导意义。Objective： To optimize emulsification of starch sodium octenyl succinate （SSOS） -Zedoary oil by application of response surface analysis. Methods：High performance liquid chromatography （HPLC） was used to measure and compare how different substituted ratio, concentration and wall-core ratio affect the microencapsulation efficiency of curcumo] and ^-elemene in starch sodium octenyl suc- cinate （SSOS） -Zedoary oil, and response surface analysis was used to optimize the emulsification condition. Results：Response surface analysis showed that the most optimized emulsification condition of SSOS was 0. 07 substituted ratio, 0. 05 wall-core ratio and O. 17 wall- core ratio. The microencapsulation efficiency of curcumol was 100. 00%, and that of β-elemene was 34. 891%. Conclusion： Response surface analysis is practically instruction for optimizing emulsification of SSOS-zedoary oil.

关 键 词：辛烯基琥珀酸淀粉脂 响应面法 莪术油 乳化 包封率 

分 类 号：R977.2[医药卫生—药品]