苯并咪唑类化合物的合成及其抑菌活性  

Synthesis and bacteriostatic activity of benzimidazole compounds

作　　者：黄涛[1] 程康华[1] 顾晓利[1] 

机构地区：[1]南京林业大学化学工程学院,江苏南京210037

出　　处：《南京林业大学学报（自然科学版）》2013年第2期151-155,共5页Journal of Nanjing Forestry University：Natural Sciences Edition

基　　金：国家林业公益性行业科研专项项目(201104032)

摘　　要：为探索具有高活性的有机木材防腐剂,以4-取代邻苯二胺为原料,经酰化、环合等步骤合成了7种5-取代苯并咪唑类衍生物,并经熔点、MS、1H-NMR及元素分析确证其结构。用滤纸片法研究目标化合物对白腐菌(彩绒革盖菌(Coriolus versicolor))、褐腐菌(密粘褶菌(Gloeophyllum trabeum))、霉菌(黑曲霉(Aspergillus niger)和绿色木霉(Trichoderma viride))的抑制活性,结果表明:合成的7种化合物对木材中的腐朽菌均没有抑菌活性,但部分化合物对木材腐朽菌中的霉菌有明显的抑制效果;化合物4a在质量分数为1.0%时对两种霉菌就表现出较强的抑菌效果,且其效果明显优于对照试剂(五氯酚钠),化合物4b的抑菌效果则与对照试剂相当。To find new organic wood preservative with broad-spectrum and hyperactivity,seven 5-substituted benzimidazole compounds were synthesized from 4-substituted ο-phenylenediamine through multi-step reactions including acylation,cyclization and so on.Their chemical structures were confirmed by melting points,MS,1H NMR and elemental analysis.The target compounds were screened for antimicrobial activity by agar-well diffusion method against white-rot fungi（Coriolus versicolor）,brown-rot fungi（Gloeophyllum trabeum） and moulds（Aspergillus niger and Trichoderma viride）.The preliminary fungicidal tests showed that seven compounds had no fungicidal activities,but some of them had anti-mould activities.Compound 4a at concentration of 1.0% showed strong anti-mould activity which was significantly higher than that of pentachlorophenate,and compounds 4b was equal to contrast.

关 键 词：苯并咪唑 木材防腐 抑菌活性 

分 类 号：O626[理学—有机化学]