不同认知功能水平对阿尔茨海默病患者外周血辅助性T细胞表达影响  

Different levels of cognition on the expression of helper T cell in Alzheimer patients

作　　者：林巧[1] 孟秀君[1] 任玉峰[1] 李明[1] 方蔷[1] 刘俊[1] 张圆圆[1] 

机构地区：[1]中国医科大学附属第四医院,110005

出　　处：《山西医药杂志（上半月）》2013年第4期366-368,共3页Shanxi Medical Journal

基　　金：辽宁省科技计划项目(2010225034)

摘　　要：目的观察不同认知功能水平对阿尔茨海默病(AD)患者外周血辅助性T细胞表达影响。方法连续选择近期就诊或住院治疗的AD患者39例,对照组选择同期在我院参加体检健康成人25名,2组入选对象均检测外周血辅助性T细胞(CD3+、CD4+、CD8+、CD4+/CD8+),AD组同时接受了AD评定量表认知部分(ADAS-Cog)评估。结果 AD组的外周血CD3+和CD4+表达水平及CD4+/CD8+比值显著高于对照组,而CD8+则显著低于后者(P均<0.05);中、重度认知损害重组(ADAS-Cog总分≥20分,17例)的外周血CD3+和CD4+表达水平及CD4+/CD8+比值也显著高于轻度认知损害组(ADAS-Cog总分<20分,22例),而前者CD8+则则明显低于后者(P均<0.05)。结论 AD患者存在明确的辅助性T细胞高水平表达,且伴随着认知损伤加深显著而进一步严重。Objective To explore the effect of different levels of cognition on the expression of helper T cell in Alzheimer patients＇ peripheral blood. Methods Thirty-nine AD patients were included in the AD group, while 25 healthy adults were included in the control group. Helper T cells （CD3^＋ , CD4^＋ , CD8^＋ , CD4^＋/CD8^＋ ） were tested in both groups. Patients in AD group were evaluated by Alzheimer＇s Disease Assessment Scale cognitive subscale （ADAS-Cog）. Results Expression of CD3^＋ and CD4^＋ in AD group and the ratio of CD4^＋/CD8^＋ were significantly higher than those in the control group, while expression of CD8^＋ was significantly lower than that in the control group. Expression of CD3^＋ and CD4^＋ in moderate and severe cognitive impairment group and the ratio of CD4^＋/CD8^＋ were significantly higher than that in the mild cognitive impairment group, while expression of CD8^＋ was significantly lower in moderate and severe cognitive impairment group（All P〈0.05）. Conclusion Expression of helper T cells was significantly higher in AD patients, and increased as the cognitive level declined.

关 键 词：阿尔茨海默病 T细胞 辅助诱导 认知障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学]