配伍禁忌半夏、贝母对乌头汤抗氧化活性的影响  

Effect of Pinelliae Rhizoma and Fritillariae Thunbergli Bulbus on Antioxidant Activity of Wutou Decoction

作　　者：李世哲[1] 陈瑞战[1] 齐瑶[2] 皮子凤[2] 宋凤瑞[2] 刘志强[2] 

机构地区：[1]长春师范学院,长春130032 [2]中国科学院长春应用化学研究所,长春130022

出　　处：《中国实验方剂学杂志》2013年第8期198-202,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展计划("973计划")(2011CB505300-05);国家自然科学基金项目(81274046);吉林省自然科学基金项目(201215147)

摘　　要：目的:考察乌头汤中加入半夏、贝母对抗氧化活性的影响,从抗氧化活性角度验证乌头反半夏与贝母的科学性。方法:分别以FRAP法测定总抗氧化活性,对DPPH.的清除能力测定清除自由基的活性。对比乌头汤中加入生半夏、川贝母与乌头汤的抗氧化活性,同时考察单煎制川乌、制川乌分别与反药及其他组方药配伍的抗氧化活性。结果:乌头汤与生半夏、川贝母配伍均会对抗氧化活性有一定的抑制作用,其中与川贝母的配伍降低作用最为明显。结论:乌头汤与生半夏,川贝母配伍会降低其抗氧化活性。Objective：The effect of Pinelliae Rhizoma and Fritillariae Thunbergli Bulbus on antioxidant activity of Wutou decoction（WTD） was studied to validate the scientific of aconite incompatibility.Method：The total antioxidant activity of different samples was determined by ferric reducing antioxidant power（FRAP） assay and DPPH·scavenging assay.The different antioxidant activities of WTD were compared to the WTD added with Pinelliae Rhizoma（RP） and Sichuan fritillary（SF） respectively.Moreover,the antioxidant activities of Monkshood Prepared（PM）,PM with opposing herbal remedies and PM with the other herb medicine in WTD.Result：The antioxidant activities of WTD were inhibited by RP and SF.The inhibition activity of SF was more obviously.In the combination between WTD and ZF or PM and ZF,the total antioxidant activity was both enhanced.Conclusion：The antioxidant activities were decreased in the combination between WTD and RP or WTD and SF.

关 键 词：乌头汤 抗氧化活性 半夏 贝母 配伍 

分 类 号：R285.5[医药卫生—中药学]