实验研究正丁胺基罗沙替丁乙酸酯治疗胃溃疡  

Rats with gastric ulcer were treated by butylamine roxatidine acetas

作　　者：陈向华[1] 

机构地区：[1]武汉体育学院医院,湖北武汉430079

出　　处：《中国现代医学杂志》2013年第4期23-25,共3页China Journal of Modern Medicine

摘　　要：目的探讨正丁胺基罗沙替丁乙酸酯(BRA)对胃溃疡大鼠三叶因子2(trefoil factors2,TFF2)、血清脑肠肽(Ghrelin)、生长抑素(somatostatin,SOM)mRNA表达的影响。方法 Wistar大鼠60只随机分为对照组、雷尼替丁组、BRA组。雷尼替丁组、BRA组大鼠造模。对照组予生理盐水灌胃;雷尼替丁组予雷尼替丁灌胃;BRA组以BRA灌胃。ELISA法检测血清TFF2及Ghrelin水平,逆转录PCR(RT-PCR)法检测SOM mRNA的表达。结果 BRA组血清TFF2水平、SOM mRNA显著高于雷尼替丁组;治疗组Ghrelin水平低于雷尼替丁组P均<0.05。结论 BRA可提高胃黏膜组织再生及修复能力,保护胃黏膜促进胃溃疡愈合,为临床应用提供理论依据。【Objective】 To study the effects of butylamine roxatidine acetas（BRA） on TFF2,Ghrelin and SOM mRNA in rats with gastric ulcer.【Methods】 60 Wistar rats were randomized into control group,ranitidine group and BRA group.Rats of ranitidine group and BRA group were molded Control group were given saline water,ranitidine group by ranitidine and BRA group by BRA intragastric administration.The level of TFF2 was tested by ELISA,and SOM mRNA by RT-PCR.【Results】 TFF2 and SOM mRNA of BRA group were significantly higher than that of ranitidine group.However,the level of Ghrelin was remarkable lower than that of ranitidine group.【Conclusion】 The results show butylamine roxatidine acetas can promote ulcer healing and protect gastric mucosa on experimental gastric ulcer.This study provides the theory basis for clinical application.

关 键 词：正丁胺基罗沙替丁乙酸酯 胃溃疡 三叶因子2 脑肠肽 生长抑素MRNA 

分 类 号：R573.1[医药卫生—消化系统]