鼻咽癌与乙肝病毒感染关系的配对病例-对照研究  

Matched case-control studies on risk factors of nasopharyngeal carcinoma

作　　者：韦保和 张少华[2] 李海凤[2] 毛得斌 莫志恒[1] 

机构地区：[1]梧州市红十字会医院肿瘤科,广西梧州543002 [2]梧州市红十字会医院检验科,广西梧州543002

出　　处：《中国现代医学杂志》2013年第4期94-97,共4页China Journal of Modern Medicine

基　　金：广西梧州市科学研究与技术开发项目(No:200802019)

摘　　要：目的为了解鼻咽癌患者乙型肝炎病毒感染状况,并探讨鼻咽癌与乙型肝炎病毒感染的关系。方法采取病例-对照研究方法选择研究对象,应用时间分辨荧光免疫分析法(TRFIA)检测研究对象血清HBV5项标志物(HBsAg、HBsAb、HBeAg、HBeAb和HBcAb)。结果 745对鼻咽癌与对照组HBsAg阳性率分别是15.83%和9.77%,χ2=15.5,P<0.01。745对鼻咽癌与对照者的配对检验,χ2=12.42,P<0.01;OR=1.76。结论鼻咽癌患者HBsAg阳性率高于非恶性肿瘤患者。乙肝病毒感染可能是鼻咽癌的危险因素。【Objective】 To study the relation between the infection of hepatitis B virus（HBV） and nasopharyngeal carcinoma（NPC）.【Methods】 The serum levels of HBV（HBsAg,HBsAb,HBeAg,HBeAb and HBcAb） 5 marker of cases and controls were detected by time-resolved fluorescence immunoassay（TRFIA）.The cases were paired with controls at the same time hospitalization blindly.Time resolved fluorescence immunoassay（TRFIA） methods were used to detect to serum HBV（HBsAg,HBsAb,HBeAg,HBeAb and HBcAb） 5 markers for cases and the control group.The cases and controls were paired with blind.【Result】 The HBsAg positive rate in 745 pair of cases and controls were 15.83% and 9.77%,respectively.χ2=15.5,P 0.01.The value of paired χ2 test was 12.42,P 0.01,OR=1.76.【Conclusion】 The positive rate of HBsAg in NPC patients is higher than that in non-cancer patients.HBsAg positive is risk factor for nasopharyngeal carcinoma.

关 键 词：鼻咽癌 乙型肝炎病毒 病例-对照研究 

分 类 号：R739.63[医药卫生—肿瘤]