Comparative systems biology between human and animal models based on next-generation sequencing methods  

作　　者：Yu-Qi ZHAO Gong-Hua LI Jing-Fei HUANG 

机构地区：[1]State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences [2]Kunming Institute of Zoology, Chinese University of Hong Kong Joint Research Center for Bio-resources and Human Disease Mechanisms

出　　处：《Zoological Research》2013年第2期J0001-J0007,共7页动物学研究（英文）

基　　金：supported by the National Natural Science Foundation of China (31123005);the Chinese Academy of Sciences (Y002731071);the National Basic Research Program of China (2009CB941300)

摘　　要：Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism. To improve the efficacy of animal models, a technological breakthrough is required. The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform. In the present study, we introduce the concept of the comparative systems biology, which we define as "comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels". Furthermore, we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies.Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism. To improve the efficacy of animal models, a technological breakthrough is required. The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform. In the present study, we introduce the concept of the comparative systems biology, which we define as ＂comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels＂. Furthermore, we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies.

关 键 词：Animal models Comparative systems biology Next-generation sequencing RNA-SEQ ChlP-seq 

分 类 号：Q-0[生物学] S823.2[农业科学—畜牧学]