放疗联合多西他赛治疗中晚期食管癌疗效观察  

Clinical Observation of Radiotherapy Combined with Docetaxel in the Treatment of Advanced Esophageal Carcinoma

作　　者：王青民[1] 杨敬磊[2] 张玉萍[1] 

机构地区：[1]青岛市肿瘤医院放疗科,山东青岛266042 [2]青岛市肿瘤医院放射物理科,山东青岛266042

出　　处：《肿瘤基础与临床》2013年第2期116-118,共3页journal of basic and clinical oncology

摘　　要：目的观察放疗联合多西他赛治疗中晚期食管癌的疗效及毒副反应。方法将32例中晚期食管癌患者随机分为单放组和综合组。单放组16例仅行单纯放疗,综合组16例采用放疗联合多西他赛治疗。治疗后,比较观察2组的疗效和毒副反应。结果单放组和综合组完全缓解率分别为18.75%、50.00%,差异有统计学意义(P<0.05);2组毒副反应比较差异无统计学意义(P>0.05)。结论放疗联合多西他赛治疗中晚期食管癌有较好的近期疗效,且不增加毒副反应。Objective To explore the efficacy and toxicities of radiotherapy combined with docetaxel in the treat- ment of advanced esophageal carcinoma. Methods Thirty-two cases of esophageal carcinoma were randomly divid- ed into two groups： 16 cases of the single radiotherapy group received radiotherapy alone, 16 cases of the combined modality therapy group received radiotherapy combined with docetaxel. After treatment, the efficacy and toxicities of the two groups were observed comparatively. Results The complete remission rate was 18.75% in the single radiotherapy group,and was 50.00% in the combined modality therapy group （P 〈 0.05）. There was no significant difference in the toxicities between the two groups. Conclusion Radiotherapy combined with docetaxel is effective for esophageal carcinoma,but the toxicities are not increased.

关 键 词：放疗 多西他赛 食管癌 

分 类 号：I1735.1[文学—世界文学] R730.55[医药卫生—肿瘤]