培美曲塞联合顺铂治疗对老年非小细胞肺癌血清MMP-2和TIMP-2水平的影响  

Effect of Pemetrexed combined with cisplatin on serum levels of MMP-2 and TIMP-2 in elderly patients with non-small-cell lung cancer treated with pemetrexed and cisplatin

作　　者：单杨杨[1] 李晟磊[1] 

机构地区：[1]郑州大学基础医学院病理教研室科,450001

出　　处：《中国实用医刊》2013年第8期68-69,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨培美曲塞联合顺铂化疗对老年非小细胞肺癌患者血清基质金属蛋白酶-2（MMP-2）和基质金属蛋白酶抑制剂-2（TIMP-2）水平的影响。方法选取老年非小细胞肺癌患者62例，采用曲塞联合顺铂化疗，应用放射免疫分析法检测所有患者化疗前后血清中MMP-2、TIMP-2的水平，并与60例老年肺部良性病变患者进行比较。结果老年非小细胞肺癌患者化疗前血清MMP-2、TIMP-2的水平显著高于肺部良性病变组及化疗后（P〈0．01），化疗后其水平明显下降或接近肺部良性病变组。结论曲塞联合顺铂化疗可显著降低老年非小细胞肺癌患者血清中MMP-2、TIMP-2的水平，对抑制肺癌细胞的侵袭和转移具有一定的作用。Objective To investigate the changes of serum MMP-2 and TIMP-2 levels after chemotherapy with pemetrexed and cisplatin in elderly patients with non-small-cell lung cancer （NSCLC）. Methods Serum MMP-2, TIMP-2 （with RIA）levels were determined in 62 elderly patients with NSCLC before and after chemotherapy with pemetrexed and cisplatin, and compared with the levels of 60 elderly patients with pulmonary benign lesions. Results The levels of MMP-2, TIMP-2 before chemotherapy in elderly patients with NSCLC were significantly higher than those with pulmonary benign lesions and the levels after chemotherapy（ P 〈 0. 01 ）. The levels after chemotherapy dropped markedly and approached those with pulmonary benign lesions. Conclusions The MMP-2, TIMP-2 levels in serurns of elderly patients with NSCLC can be reduced significantly after chemotherapy with pemetrexed and cisplatin. It has a certain effect on inhibition the invasion and metastasis of lung cancer cell.

关 键 词：培美曲塞 顺铂 老年患者 非小细胞肺癌 血清基质金属蛋白酶-2 基质金属蛋白酶抑制剂-2 

分 类 号：R734.2[医药卫生—肿瘤]