影像引导下^125I粒子组织间植入近距离治疗肿瘤的应用进展  

Application and progress of image-guided ^125I seed interstitial implantation for the treatment of tumor

作　　者：甄作武[1] 林坚[2] 杨锦钊[2] 庞景灼[3] 郑广钧[4] 柴树德[4] 

机构地区：[1]广东省江门市中心医院核医学科,529030 [2]广东省江门市中心医院放射科,529030 [3]广东省江门市中心医院胸外科,529030 [4]天津医科大学附属第二医院胸外科,300211

出　　处：《国际放射医学核医学杂志》2013年第2期116-119,共4页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：放射性粒子植入治疗虽有较久的历史，但只是近10年来才对其物理、生物学特性特别是临床剂量学与疗效、并发症的关系进行了深入探讨。粒子植入治疗肿瘤是将放射性粒子按照放射治疗计划均匀、规律地植入恶性肿瘤组织中，让肿瘤得到较高剂量的放射性照射，而正常组织不受损伤或仅有微小损伤的治疗方法。粒子植入技术可普遍用于难以手术切除、达不到根治切除和有手术残余的肿瘤治疗，还可用于肿瘤切除术后的肿瘤周缘植入，以预防肿瘤复发和转移。近10年来，放射性粒子植入治疗肿瘤技术发展较为迅速，国内至少600家医院开展了这项技术，而且将治疗适应证在争议中扩大到了肝、肺、食道、胰腺、直肠、前列腺、甲状腺、头面部和鼻咽等实体肿瘤中。Although radioactive seed interstitial implantation had been used for a long time, the relationship between the physical, biological characteristics, the clinical dose and curative effect, complications had been deeply discussed for decade. Treat the tumor by seed interstitial implantation technology, implanting the radioactive seeds into malignant tumor tissues well-distributed and regularly according to the radiotherapy plans, then the tumor receive higher doses of radiation, while the normal tissue get less or no injure. This seed implanted technology is used for treatment tumors that hard to surgical resection, could not reached complete excision and surgery residual, and implant seeds in tumor edge avoid recurrence and metastasis. Radioactive seed implantation technology for cancer developed rapidly in 10 years, more than 600 hospitals carried out the technology in China recently, and the technology indication will expand to the solid tumors origin from organs such as liver, lung, esophagus, pancreas, rectum, prostate gland, thyroid, head, facial, nasopharynx and so on.

关 键 词：肿瘤 碘放射性同位素 近距离放射疗法 

分 类 号：R730[医药卫生—肿瘤]