神经生长因子联合西酞普兰对海洛因依赖者脱毒期抑郁及心理渴求症状的疗效观察  

Therapeutic effects of nerve growth factor combined with citalopram for depressive and psychological desire of heroin addicts

作　　者：王强[1] 汪青松[1] 吴庆[2] 张园园 

机构地区：[1]解放军105医院神经内科,安徽合肥230031 [2]安徽省合肥市第四人民医院,安徽合肥230022 [3]安徽省合肥监狱,安徽合肥230021

出　　处：《安徽医药》2013年第4期632-634,共3页Anhui Medical and Pharmaceutical Journal

基　　金：南京军区医学科技创新课题(No 11MA042)

摘　　要：目的评价神经生长因子联合西酞普兰对海洛因依赖者的抑郁及心理渴求症状的治疗效果。方法将93例男性患者随机分为两组,其中西酞普兰治疗组41例;神经生长因子(NGF)联合西酞普兰治疗组42例,治疗前两组罪犯的年龄、刑期及BDI-13评分比较均无统计学差异。除戒毒用药美沙酮及丁丙诺啡外,两组分别应用神经生长因子联合西酞普兰和西酞普兰进行治疗,疗程为6周。采用Beck抑郁自评问卷(BDI-13)及及心理渴求自评量表进行评定疗效。结果神经生长因子联合西酞普兰组治疗后2、4、6周末BDI-13评分及减分率较西酞普兰组差异有统计学意义(t=3.25、6.12、7.15;t=3.56、4.59、6.21,P<0.05);神经生长因子联合西酞普兰组治疗后14、28、35、42 d末心理渴求评分明显减少较西酞普兰组差异有统计学意义(t=2.24、3.12、3.21、2.56,P<0.05)。结论神经生长因子联合西酞普兰可有效地减轻海洛因依赖者在脱毒期及脱毒后的抑郁及心理渴求症状。Objective To evaluate the therapeutic effects of nerve growth factor combined with citalopram for depressive and psychologi- cal desire of heroin. Methods 93 male patients were randomly assigned into two groups, including citalopram treatment group （ 41 ） and nerve growth factor（NGF） combined with citalopram treatment group （42）. There was no significant differences in offenders age, length of sentence and BDI-13 rating between the two groups before the treatment. In addition to drug medication methadone and buprenorphine, joint application of nerve growth factors for treatment was conducted for six weeks. Beck Depression self-assessment questionnaire（ BDf- 13）and the craving were used to evaluate the efficacy of self-rating scale. Results In nerve growth factor combined with citalopram group BDI-13 score and the reduction rates at the end of 2,4,6 week after treatment were statistically different from those in citalopram group （ t = 3.25,6.12,7.15 ; t = 3.56,4.59,6.21, P 〈 0.05 ） ; craving score at 14,28,35,42 day significantly reduced, which was signif- icantly different from citalopram group（ t =2.24,3.12,3.21,2.56 ,P 〈0.05 ）. Conclusion Nerve growth factor combined with citalo- pram may be effective alleviating heroin addicts in during and after detoxification of coke depression and psychological desire symptoms.

关 键 词：神经心理学 神经生长因子 西酞普兰 海洛因依赖者 抑郁 

分 类 号：R749.6[医药卫生—神经病学与精神病学]