维生素D与非酒精性脂肪性肝病关系的研究进展  

Relationship between vitamin D and nonalcoholic fatty liver disease

作　　者：朴熙绪[1] 韩红梅[1] 

机构地区：[1]延边大学附属医院消化内科,吉林省延吉市133000

出　　处：《世界华人消化杂志》2013年第9期766-772,共7页World Chinese Journal of Digestology

摘　　要：维生素D是一种具有广泛生物学活性的重要开环甾醇类激素,对机体细胞增殖、分化、凋亡、免疫调节等均有重要作用. 近年的研究表明维生素D不足或缺乏与非酒精性脂肪性肝病(non alcoholic fatty liver disease, NAFLD)相关. NAFLD患者血清25(OH)D水平低于对照人群,低血清25(OH)D水平与患者的肝组织脂肪变性、炎症、纤维化程度有相关关系. 维生素D缺乏饮食可加重NAFLD模型动物肝组织炎症,补充维生素D可减轻肝组织病理改变.维生素D对NAFLD作用可能通过其受体VDR介导, 经众多基因调控实现。维生素D对肝星状细胞的调节可能是其抗非酒精性脂肪性肝纤维化的重要机制。至今的研究提示维生素D有望成为NAFLD的治疗药物,但需要更多高质量实验和循证医学的证据。Vitamin D is an important secosteroid hormone with pleiotropic effects, including regulation of cell proliferation, differentiation, apoptosis, and immunomodulation. Recently certain evidence has indicated that insufficiency of vitamin D or vitamin D deficiency is related to nonalco-holic fatty liver disease （NAFLD）. Subjects with NAFLD have lower serum vitamin D levels than controls, and low vitamin D levels are closely associated with histologic severity of steatosis, necrosis, inflammation and fibrosis in NAFLD. Vitamin D-deficient diet aggravated high fat diet-induced hepatic inflammation in NAFLD models, while vitamin D supplementation improved hepatic histopathology. Vitamin D may act as a regulator in NAFLD through activating VDR and controlling various genes. Modulating hepatic stellate cells is an important mechanism underlying the antifibrotic effect of vitamin D in NAFLD. Vitamin D is a potential drug for treatment for NAFLD, and further prospective RCT studies are required to acquire sufficientevidence.

关 键 词：维生素D 维生素D受体 非酒精性脂肪性肝病 肝纤维化 

分 类 号：R575.5[医药卫生—消化系统]