不同种族角膜植片对穿透性角膜移植术效果的影响  

Clinical evaluation of penetrating keratoplasty with different race donor corneas

作　　者：张樱楠[1] 闫超[1] 王立[1] 刘静[1] 潘志强[1] 

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室北京同仁眼库,100730

出　　处：《眼科》2013年第2期98-100,共3页Ophthalmology in China

摘　　要：目的通过观察不同种族问穿透性角膜移植手术的效果，总结不同种族之间穿透性角膜移植的可行性。设计回顾性病例系列。研究对象北京同仁眼科中心2002年10月至2003年3月因角膜白斑、角膜内皮失代偿、角膜移植术后植片失败等接受穿透性角膜移植术患者10例（10眼）。方法采用国际组织库提供的中期保存角膜植片进行穿透性角膜移植术，其中高加索人种角膜8片，西班牙人种1片，非洲人种1片。术前收集患者资料，术后进行随访和临床观察，评价角膜植片的存活情况以及疗效。主要指标视力，角膜植片透明度，角膜新生血管分级。结果10例患者平均随访（12．6±3．86）个月，4例患者角膜植片基本保持透明，视力平均提高1-2行。6例（60％）患者出现植片混浊、植片水肿、新生血管长人等排斥反应，视力不提高。结论本文小样本观察显示不同种族角膜供体可以用于穿透性角膜移植治疗。Objective To evaluate the clinical effect of penetrating keratoplasty （PKP） performed with internationally acquired corneas from donors of a different race. Design Retrospective ease series. Participants 10 eyes from 10 patients with corneal leucoma, corneal endothelial dysfunction or corneal graft failure that underwent PKP in Beijing Tongren Eye Center, Beijing Tongren Hospital between October 2002 to March 2003 （10 corneas from Caucasians： 8 eyes, Hispanic：l eye, African-American：l eye）. Method All cases underwent PKP with corneas from donors of a different race from the Tissue Bank International （TBI）, and for whom a mean of 12.6_＋3.86 months of follow-up was available. Main Outcome Measure Visual acuity, corneal transparency, stromal edema and graft neovascularization. Results Among the 10 eyes that met inclusion criteria, there were 4 eyes graft survival at 1 year. The opacity, edema and neovascularization of the graft wore observed in the other 6 eyes. The overall rate of rejection was 60%. Conclusions This small sample study shows the internationally acquired corneas different race donor corneal tissue can be used for PKP.

关 键 词：角膜移植 种族 植片存活 

分 类 号：R779.65[医药卫生—眼科]