NF-κB信号与白血病  

NF-κB Signal and Leukemia

作　　者：刘新利[1] 李静[1] 章骏[1] 

机构地区：[1]上海师范大学生命与环境科学学院,上海200234

出　　处：《中国细胞生物学学报》2013年第4期516-525,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31201104);国家重点基础研究发展计划(973)项目(批准号:2013CB966800)资助的课题~~

摘　　要：核转录因子κB(nuclear factor-kappa B,NF-κB)存在于多种组织细胞中,具有广泛的生物学活性,在细胞的生存、增殖、分化以及炎性因子的产生中发挥着重要的作用。NF-κB信号通过调控靶基因的表达参与多种生理过程。NF-κB信号的失调可导致炎症反应和肿瘤等疾病的发生。研究表明,NF-κB信号在多种白血病细胞中,特别是白血病干细胞中持续活化。NF-κB抑制剂可特异性地杀死白血病干细胞,为潜在的抗白血病药物,但由于其潜在的毒副作用,使其临床应用受限。该文就NF-κB信号传导的分子机理、NF-κB信号通路在白血病发生发展中的作用以及NF-κB抑制剂在临床治疗白血病中的应用作一综述。Nuclear factor-κB （NF-κB） is broadly expressed in many types of tissue cells. It is involved in the regulation of a wide range of cell biological behaviors such as cell survival, proliferation, differentiation and inflammatory cytokine production. By its control of target gene expression, the NF-κB signal participates in the regulation of a variety of physiological processes. Deregulation of NF-κB signaling has been detected in large numbers of diseases, including infectious diseases and cancers, contributing to the pathogenesis and progression of such diseases. Studies have shown that NF-κB signaling is constitutively activated in a variety of leukemic cells, especially leukemia stem cells. Inactivation of NF-κB signaling can specifically kill leukemia stem cells while at the same time causing limited toxicity to normal hematopoietic stem cells, suggesting a potential target for designing novel anti-leukemia drugs. However, because of their potential for adverse side effects affecting other organs, the clinical application of NF-κB inhibitors is limited. In this review, we summarize the molecular mechanism by which the NF-κB signal is activated and transduced. We also discuss the role of NF-κB signaling in the initiation and progression of leukemia, as well as the potential application of NF-κB inhibitors in the clinical treatment of leukemia.

关 键 词：NF—κB 白血病 白血病干细胞 NF-ΚB抑制剂 

分 类 号：R733.7[医药卫生—肿瘤]