Genipin交联丝素蛋白纳米纤维膜的制备与性能  

Preparation and properties of Genipin cross-linked silk fibroin nanofibrous membranes

作　　者：边瑞琦[1] 王利君[1] 熊杰[1] 

机构地区：[1]浙江理工大学先进纺织材料与制备技术教育部重点实验室,杭州310018

出　　处：《复合材料学报》2013年第2期83-88,共6页Acta Materiae Compositae Sinica

基　　金：973计划前期研究课题(2008CB617506);浙江省自然科学基金重点项目(Z4100798);长江学者和创新团队发展计划资助(IRT0654);先进纺织材料与制备技术教育部重点实验室开放基金资助项目(2006003)

摘　　要：利用Genipin对再生丝素蛋白进行交联改性,并通过静电纺丝法制备交联的丝素蛋白纳米纤维膜。利用场发射扫描电镜、红外光谱仪、X射线衍射仪、热重分析仪以及拉力机等对其结构与性能进行表征与测试。结果表明,随着交联剂Genipin质量比的增加,交联度增加,静电纺丝素蛋白纳米纤维平均直径增大,标准偏差增大;Genipin交联对丝素蛋白纳米纤维结晶结构影响不大,但热性能提高;常温条件下,随着Genipin质量比从2%提高至15%,丝素蛋白纳米纤维膜的力学性能逐渐增强,质量比为10%时,其力学性能较好,拉伸强度和断裂应变分别为19.6MPa和5.9%;随着试验温度从40℃升高到200℃,丝素蛋白纳米纤维膜的拉伸强度和断裂应变先增大然后减小,当试验温度为80℃时,其力学性能较好,拉伸强度和断裂应变分别为41.6MPa和8.6%。The regenerated silk fibroin（SF） was modified by Genipin cross-linking,and then was made into cross-linked nanofibrous membranes via electrospinning.The structure and properties of nanofibers were characterized and tested by use of FE-SEM,FTIR,XRD,TGA and tensile tester.The results show that the degree of cross-linking,average diameter of nanofibers and standard deviation increase with the increasing of Genipin mass ratio.And the crystal structure of SF nanofibers is not influenced by Genipin cross-linking,but thermal properties are improved.Under room temperature,the mechanical properties of SF nanofibrous membranes are enhanced with the increasing of Genipin mass ratio from 2% to 15%.And the mechanical property is better when the Genipin mass ratio is 10%,the tensile strength and breaking strain are 19.6 MPa and 5.9% respectively.The tensile strength and breaking strain of SF nanofibrous membranes first increase and then decrease with the rising of tensile temperature from 40 ℃ to 200 ℃,the mechanical property is better at 80 ℃,the tensile strength and breaking strain are 41.6 MPa and 8.6% respectively.

关 键 词：GENIPIN 丝素蛋白 交联 静电纺丝 纳米纤维 

分 类 号：TB332[一般工业技术—材料科学与工程]